Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | LATS1 | O95835 | 4/20 | 0.37 |
| ▸ | LATS2 | Q9NRM7 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | AOC1 | P19801 | 1/20 | 0.30 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20940090 | 0.87 | RPS6KA3 (0.36) | RPS6KA3LOXL2LATS1LATS2LMNA | |
| SCHEMBL21108882 | 0.86 | RPS6KA3 (0.36) | RPS6KA3LOXL2LATS1LATS2LMNA | |
| SCHEMBL20940108 | 0.85 | RPS6KA3 (0.41) | RPS6KA3LOXL2LATS1LATS2SMN1; SMN2 | |
| SCHEMBL14612403 | 0.85 | RPS6KA3 (0.41) | RPS6KA3LOXL2LATS1LATS2SMN1; SMN2 | |
| SCHEMBL10115538 | 0.85 | RPS6KA3 (0.41) | RPS6KA3LOXL2LATS1LATS2SMN1; SMN2 | |
| SCHEMBL23219667 | 0.84 | LOXL2 (0.40) | RPS6KA3LOXL2LATS1LATS2LMNA | |
| SCHEMBL19003682 | 0.81 | LOXL2 (0.38) | RPS6KA3LOXL2LATS1LATS2KDM4E | |
| SCHEMBL19133210 | 0.79 | LMNA (0.37) | LMNAMAPTMAPK1HTR2AHTR2C | |
| SCHEMBL20621645 | 0.79 | AOC1 (0.40) | LMNAMAPTMAPK1HTR2AHTR2C | |
| SCHEMBL24988968 | 0.78 | LIMK1 (0.35) | RPS6KA3LATS1LMNAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10959986-B2 | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-03-30 | — | — | US | disclosed |
| US-20200069646-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE | BRISTOL MYERS SQUIBB CO (US) | 2020-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10959986-B2 | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use | IDO1, IDO2, INMT | RPS6KA3 1859/4885LOXL2 761/4885LATS1 2220/4885 |
| US-20200069646-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE | IDO1, IDO2, INMT | RPS6KA3 1859/4885LOXL2 761/4885LATS1 2220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.