Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS1 | P56192 | 9/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | RPA1 | P27694 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3819281 | 0.93 | MARS1 (0.54) | MARS1PTGS1PTGS2MAPK1CYP1A2 | |
| SCHEMBL1011693 | 0.87 | ALDH1A1 (0.46) | MARS1SMPD1PTGS1PTGS2CYP1A2 | |
| SCHEMBL1009295 | 0.85 | MARS1 (0.48) | MARS1PTGS1PTGS2MAPK1CYP1A2 | |
| SCHEMBL1010395 | 0.79 | ALDH1A1 (0.53) | MARS1SMPD1PTGS1PTGS2CYP1A2 | |
| SCHEMBL10756953 | 0.75 | L3MBTL1 (0.61) | MARS1SMPD1MAPK1CYP1A2HIF1A | |
| SCHEMBL1009792 | 0.73 | ALDH1A1 (0.44) | MARS1PTGS1PTGS2CYP1A2KMT2A | |
| SCHEMBL9179375 | 0.73 | MAPK1 (0.76) | MAPK1 | |
| SCHEMBL1010582 | 0.73 | PTGS1 (0.42) | MARS1SMPD1PTGS1PTGS2KMT2A | |
| SCHEMBL27739364 | 0.71 | CNR1 (0.58) | CNR1CNR2 | |
| SCHEMBL122207 | 0.71 | MAPK1 (0.76) | MAPK1CYP1A2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094706-B1 | SUBSTITUTED 2,5-DFFLYDRO-3H-PYRAZOLO[4,3-C]PYRIDAZIN-3-ONE DERIVATIVES, PREPARATION THEREOF AND USE OF SAME AS CANNABINOID CB1 RECEPTOR LIGANDS | SANOFI AVENTIS (FR) | 2011-01-05 | — | — | EP | disclosed |
| EP-2094706-A2 | SUBSTITUTED 2,5-DFFLYDRO-3H-PYRAZOLO[4,3-C]PYRIDAZIN-3-ONE DERIVATIVES, PREPARATION THEREOF AND USE OF SAME AS CANNABINOID CB1 RECEPTOR LIGANDS | Sanofi-Aventis (FR) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008068424-A2 | SUBSTITUTED 2,5-DIHYDRO-3H-PYRAZOLO[4,3-C]PYRIDAZIN-3-ONE DERIVATIVES, PREPARATION THEREOF AND USE OF SAME AS CANNABINOID CB1 RECEPTOR LIGANDS | SANOFI-AVENTIS (FR) | 2008-06-12 | — | — | WO | disclosed |