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Sugi Predict / Compounds / SCHEMBL10116253

SCHEMBL10116253

SCHEMBL10116253

Cc1c(NC(=O)c2ccc(NS(=O)(=O)C(C)(C)C)cc2)ccc2oc(=O)ccc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 3/20 0.40
▸ ALDH1A1 P00352 4/20 0.39
▸ NPC1 O15118 6/20 0.39
▸ RAB9A P51151 6/20 0.39
▸ POLB P06746 3/20 0.39
▸ CTDSP1 Q9GZU7 2/20 0.39
▸ MAPT P10636 4/20 0.38
▸ LMNA P02545 2/20 0.38
▸ KMT2A Q03164 4/20 0.37
▸ MEN1 O00255 3/20 0.37
▸ CA12 O43570 2/20 0.36
▸ CA9 Q16790 2/20 0.36
▸ CA1 P00915 1/20 0.36
▸ KDM4E B2RXH2 2/20 0.36
▸ CACNA1B Q00975 1/20 0.36
▸ APBA1 Q02410 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ GAA P10253 2/20 0.36
▸ HPGD P15428 2/20 0.36
▸ MAOA P21397 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10116539 0.85 MAP1LC3B (0.42) MAOBALDH1A1NPC1RAB9APOLB
SCHEMBL13566040 0.80 MAOB (0.39) MAOBALDH1A1POLBKMT2AMEN1
SCHEMBL10116245 0.79 KMT2A (0.61) ALDH1A1NPC1RAB9APOLBMAPT
SCHEMBL10116327 0.74 MAPT (0.43) ALDH1A1NPC1RAB9AMAPTLMNA
SCHEMBL10116259 0.74 MEN1 (0.57) ALDH1A1NPC1RAB9APOLBMAPT
SCHEMBL10116240 0.73 MEN1 (0.55) ALDH1A1NPC1RAB9APOLBMAPT
SCHEMBL10116279 0.73 RAB9A (0.50) ALDH1A1NPC1RAB9APOLBMAPT
SCHEMBL10116278 0.73 RAB9A (0.50) ALDH1A1NPC1RAB9AMAPTLMNA
SCHEMBL10115060 0.73 ALDH1A1 (0.41) ALDH1A1LMNAKMT2AMEN1KDM4E
SCHEMBL10116315 0.72 ALDH1A1 (0.44) ALDH1A1NPC1RAB9AMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-20110039802-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2011-02-17 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070015762-A1 NPY Y5 antagonist NPY5R, NPY1R, NPY2R MAOB 1153/4885ALDH1A1 4558/4885NPC1 1435/4885
US-20100292500-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R MAOB 1152/4885ALDH1A1 4599/4885NPC1 1353/4885
US-20110039802-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R MAOB 1144/4885ALDH1A1 4517/4885NPC1 1462/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.