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Sugi Predict / Compounds / SCHEMBL10116332

SCHEMBL10116332

SCHEMBL10116332

Cc1c(NC(=O)c2ccc(NS(=O)(=O)C(C)(C)C)cc2)ccc2c1CC(C)C2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.39
▸ MAPT P10636 4/20 0.38
▸ LMNA P02545 4/20 0.38
▸ CASP3 P42574 1/20 0.38
▸ SENP8 Q96LD8 1/20 0.38
▸ SENP7 Q9BQF6 1/20 0.38
▸ SENP6 Q9GZR1 1/20 0.38
▸ SIRT5 Q9NXA8 1/20 0.38
▸ HPGD P15428 4/20 0.37
▸ MAPK10 P53779 1/20 0.37
▸ MAPK1 P28482 2/20 0.37
▸ KDM4E B2RXH2 2/20 0.36
▸ NAMPT P43490 1/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ BRD4 O60885 1/20 0.35
▸ HTR1F P30939 1/20 0.35
▸ RAB9A P51151 3/20 0.35
▸ NPC1 O15118 2/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10116591 0.85 LMNA (0.40) ALDH1A1MAPTLMNACASP3SENP8
SCHEMBL10116315 0.83 ALDH1A1 (0.44) ALDH1A1MAPTLMNAHPGDMAPK10
SCHEMBL10116333 0.82 CASP3 (0.39) ALDH1A1MAPTLMNACASP3SENP8
SCHEMBL10116282 0.81 HPGD (0.48) ALDH1A1MAPTLMNAHPGDMAPK1
SCHEMBL13566012 0.80 TRPV1 (0.32) ALDH1A1LMNAHPGDKDM4EBRD4
SCHEMBL10116331 0.75 ALDH1A1 (0.46) ALDH1A1MAPTLMNAHPGDMAPK10
SCHEMBL10116311 0.74 MAPT (0.46) ALDH1A1MAPTLMNAHPGDMAPK10
SCHEMBL10116327 0.74 MAPT (0.43) ALDH1A1MAPTLMNAMAPK1KDM4E
SCHEMBL10116325 0.73 KDM4E (0.43) ALDH1A1MAPTLMNAKDM4EMEN1
SCHEMBL10134528 0.73 KDM4E (0.43) ALDH1A1MAPTLMNAKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-20110039802-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2011-02-17 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070015762-A1 NPY Y5 antagonist NPY5R, NPY1R, NPY2R ALDH1A1 4558/4885MAPT 3602/4885LMNA 1925/4885
US-20100292500-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R ALDH1A1 4599/4885MAPT 3367/4885LMNA 2068/4885
US-20110039802-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R ALDH1A1 4517/4885MAPT 3683/4885LMNA 1857/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.