SCHEMBL10118436

SCHEMBL10118436

O=C(NCCCCO)[C@@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PRCP P42785 1/20 0.52
F2 P00734 2/20 0.48
KMT2A Q03164 3/20 0.47
FKBP1A P62942 4/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
CYP3A4 P08684 1/20 0.46
MAPT P10636 1/20 0.46
CYP2C9 P11712 1/20 0.46
TSHR P16473 1/20 0.46
RAB9A P51151 1/20 0.46
PIN1 Q13526 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
HTR1A P08908 1/20 0.41
ALOX15 P16050 1/20 0.41
CTRB1 P17538 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10118420 1.00 PRCP (0.52) PRCPF2KMT2AFKBP1ASMN1; SMN2
SCHEMBL22822702 0.88 PRCP (0.54) PRCPF2KMT2AFKBP1ASMN1; SMN2
SCHEMBL30309004 0.85 F2 (0.52) PRCPF2KMT2ASMN1; SMN2CYP3A4
SCHEMBL29521538 0.84 F2 (0.51) PRCPF2KMT2ASMN1; SMN2CYP3A4
SCHEMBL15802665 0.84 PRCP (0.47) PRCPF2KMT2AFKBP1ASMN1; SMN2
SCHEMBL15801179 0.83 FKBP1A (0.46) PRCPFKBP1A
SCHEMBL5035720 0.83 PRCP (0.48) PRCPF2KMT2AFKBP1ASMN1; SMN2
SCHEMBL12972648 0.83 FKBP1A (0.51) PRCPF2KMT2AFKBP1ASMN1; SMN2
SCHEMBL10136487 0.83 F2 (0.48) F2KMT2ASMN1; SMN2TSHRL3MBTL1
SCHEMBL29368134 0.83 F2 (0.51) F2KMT2ACYP3A4MAPTCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9528111-B2 Single-stranded nucleic acid molecule having amino acid backbone BONAC CORPORATION (JP) 2016-12-27 US disclosed
US-20160108400-A1 Single-Stranded Nucleic Acid Molecule for Controlling Gene Expression BONAC CORPORATION (JP) 2016-04-21 US disclosed
US-9206422-B2 Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton BONAC CORPORATION (JP) 2015-12-08 US disclosed
US-9200278-B2 Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton BONAC CORPORATION (JP) 2015-12-01 US disclosed
US-20150011605-A1 Single-Stranded Nucleic Acid Molecule for Controlling Gene Expression BONAC CORPORATION (JP) 2015-01-08 US disclosed
US-20140329886-A1 SINGLE-STRANDED NUCLEIC ACID MOLECULE HAVING AMINO ACID BACKBONE BONAC CORPORATION (JP) 2014-11-06 US disclosed
US-8785121-B2 Single-stranded nucleic acid molecule for controlling gene expression BONAC CORPORATION (JP) 2014-07-22 US disclosed
US-20140171486-A1 Single-Stranded Nucleic Acid Molecule Having Nitrogen-Containing Alicyclic Skeleton BONAC CORPORATION (JP) 2014-06-19 US disclosed
US-20140171633-A1 Single-Stranded Nucleic Acid Molecule Having Nitrogen-Containing Alicyclic Skeleton BONAC CORPORATION (JP) 2014-06-19 US disclosed
US-8691782-B2 Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton BONAC CORPORATION (JP) 2014-04-08 US disclosed
US-20120035246-A1 SINGLE-STRANDED NUCLEIC ACID MOLECULE HAVING NITROGEN-CONTAINING ALICYCLIC SKELETON BONAC CORPORATION (JP) 2012-02-09 US disclosed
US-20120010271-A1 SINGLE-STRANDED NUCLEIC ACID MOLECULE FOR CONTROLLING GENE EXPRESSION BONAC CORPORATION (JP) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010271-A1 SINGLE-STRANDED NUCLEIC ACID MOLECULE FOR CONTROLLING GENE EXPRESSION SRRT, SSU72, RPRD2 PRCP 2054/4885F2 4862/4885KMT2A 1767/4885
US-20140329886-A1 SINGLE-STRANDED NUCLEIC ACID MOLECULE HAVING AMINO ACID BACKBONE ZFX, YBX1, SRRT PRCP 1436/4885F2 4469/4885KMT2A 807/4885
US-20140171633-A1 Single-Stranded Nucleic Acid Molecule Having Nitrogen-Containing Alicyclic Skeleton NSUN2, CTDSP1, RNGTT PRCP 1887/4885F2 4836/4885KMT2A 1455/4885
US-20120035246-A1 SINGLE-STRANDED NUCLEIC ACID MOLECULE HAVING NITROGEN-CONTAINING ALICYCLIC SKELETON NSUN2, CTDSP1, RNGTT PRCP 1887/4885F2 4836/4885KMT2A 1455/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.