Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | HASPIN | Q8TF76 | 4/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8270017 | 0.86 | SLC6A4 (0.49) | SLC6A4ADRB2PRMT5WDR77HASPIN | |
| SCHEMBL8271529 | 0.84 | MTNR1A (0.58) | SLC6A4ADRB2NQO2MTNR1AMTNR1B | |
| SCHEMBL8270044 | 0.83 | SLC6A4 (0.70) | SLC6A4HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8270943 | 0.77 | MTNR1A (0.47) | SLC6A4ADRB2NQO2MTNR1AMTNR1B | |
| SCHEMBL8238737 | 0.76 | PRMT5 (0.39) | SLC6A4ADRB2PRMT5WDR77GNAI3 | |
| SCHEMBL10119818 | 0.75 | SLC6A4 (0.46) | SLC6A4PRMT5WDR77HASPINHDAC3 | |
| SCHEMBL1971588 | 0.74 | SLC6A4 (0.55) | SLC6A4HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10119845 | 0.72 | SLC6A4 (0.52) | SLC6A4HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8270041 | 0.72 | SLC6A4 (0.43) | SLC6A4PRMT5WDR77HASPINHDAC3 | |
| SCHEMBL23917680 | 0.71 | MAPT (0.49) | ADRB2NQO2MTNR1AMTNR1BSPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781639-B1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2012-01-25 | — | — | EP | disclosed |