Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | RORA | P35398 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | RORB | Q92753 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18509197 | 0.85 | LMNA (0.46) | MAPTLMNAGAAPTPN5PGR | |
| SCHEMBL10653941 | 0.81 | CDK2 (0.44) | MAPTLMNAGAAPTPN5PGR | |
| SCHEMBL821152 | 0.81 | MEN1 (0.40) | MAPTLMNAGAAPTPN5PGR | |
| SCHEMBL18015812 | 0.80 | KCNH2 (0.57) | GPR84ADRB2HTR1DKMT2AMEN1 | |
| SCHEMBL18508879 | 0.80 | KDM4E (0.58) | LMNAGPR84ADRB2HTR1DHTR6 | |
| SCHEMBL9400590 | 0.80 | ADRB2 (0.49) | MAPTLMNAGAAPTPN5GPR84 | |
| SCHEMBL12109755 | 0.80 | MAPT (0.40) | MAPTLMNAGAAPTPN5PGR | |
| SCHEMBL15167403 | 0.78 | KMT2A (0.58) | MAPTLMNAGAAPTPN5KMT2A | |
| SCHEMBL24182195 | 0.78 | RXRA (0.43) | MAPTLMNAGAAPTPN5KMT2A | |
| SCHEMBL13888101 | 0.77 | ADRB2 (0.70) | ADRB2HTR6NQO2MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3892305-A1 | HEMIASTERLIN DERIVATIVES FOR CONJUGATION AND THERAPY | Sutro Biopharma, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |