D-Phenylalanine

D-Phenylalanine

SCHEMBL1012055

NC=O.N[C@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.85

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 4/20 0.85
PTGS1 P23219 2/20 0.85
ALPI P09923 1/20 0.85
PKM P14618 1/20 0.85
XIAP P98170 1/20 0.85
SLC1A3 P43003 2/20 0.61
SLC1A2 P43004 2/20 0.61
SLC1A1 P43005 2/20 0.61
SLC15A1 P46059 1/20 0.56
CYP1A2 P05177 1/20 0.53
LTA4H P09960 1/20 0.53
GRIA2 P42262 1/20 0.53
KDM4E B2RXH2 1/20 0.51
USP2 O75604 1/20 0.51
EGFR P00533 1/20 0.51
LCK P06239 1/20 0.51
FYN P06241 1/20 0.51
ADORA3 P0DMS8 1/20 0.51
ALOX15 P16050 1/20 0.51
HTR2A P28223 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dl-Phenylalanine SCHEMBL28155691 1.00 SLC7A5 (0.85) SLC7A5PTGS1ALPIPKMXIAP
Phenylalanine SCHEMBL1033850 1.00 SLC7A5 (0.85) SLC7A5PTGS1ALPIPKMXIAP
Dl-Phenylalanine SCHEMBL27332406 0.92 SLC7A5 (0.85) SLC7A5PTGS1ALPIPKMXIAP
Dl-Phenylalanine SCHEMBL15671104 0.92 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Phenylalanine SCHEMBL16398197 0.92 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
SCHEMBL23159186 0.92 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Dl-Phenylalanine SCHEMBL1331985 0.92 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
D-Phenylalanine SCHEMBL837632 0.92 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Dl-Phenylalanine SCHEMBL8118 0.92 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Phenylalanine SCHEMBL43671 0.92 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7709235-B2 5-Substituted hydantoin racemase, DNA encoding the same, recombinant DNA, transformed cell, and process for production of optically active N-carbamylamino acid or optically active amino acid KANEKA CORPORATION (JP) 2010-05-04 US claimed
US-20080261268-A1 5-Substituted Hydantoin Racemase, Dna Encoding the Same, Recombinant Dna, Transformed Cell, and Process for Production of Optically Active N-Carbamylamino Acid or Optically Active Amino Acid KANEKA CORPORATION (JP) 2008-10-23 US claimed
EP-1852510-A1 5-SUBSTITUTED HYDANTOIN RACEMASE, DNA ENCODING THE SAME, RECOMBINANT DNA, TRANSFORMED CELL, AND PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE N-CARBAMYLAMINO ACID OR OPTICALLY ACTIVE AMINO ACID Kaneka Corporation (JP) 2007-11-07 EP claimed
CN-107201355-B High-stereoselectivity phenylalanine deaminase mutant and application thereof 西华大学 2020-11-06 CN disclosed
EP-1275723-B1 Recombinant D-hydantoin hydrolases and N-carbamyl-D-amino acid hydrolases, and DNA encoding them; uses thereof for producing D-amino acids AJINOMOTO KK (JP) 2011-01-05 EP disclosed
US-7709235-B2 5-Substituted hydantoin racemase, DNA encoding the same, recombinant DNA, transformed cell, and process for production of optically active N-carbamylamino acid or optically active amino acid KANEKA CORPORATION (JP) 2010-05-04 US disclosed
US-20080261268-A1 5-Substituted Hydantoin Racemase, Dna Encoding the Same, Recombinant Dna, Transformed Cell, and Process for Production of Optically Active N-Carbamylamino Acid or Optically Active Amino Acid KANEKA CORPORATION (JP) 2008-10-23 US disclosed
US-7316916-B2 DNA for encoding D-hydantoin hydrolases, DNA for encoding N-carbamyl-D-amino acid hydrolases, recombinant DNA containing the genes, cells transformed with the recombinant DNA, methods for producing proteins utilizing the transformed cells and methods for producing D-amino acids AJINOMOTO CO., INC. (JP) 2008-01-08 US disclosed
US-7314738-B2 DNA for encoding D-hydantoin hydrolases, DNA for encoding N-carbamyl-D-amino acid hydrolases, recombinant DNA containing the genes, cells transformed with the recombinant DNA, methods for producing proteins utilizing the transformed cells and methods for producing D-amino acids AJINOMOTO CO., INC. (JP) 2008-01-01 US disclosed
EP-1852510-A1 5-SUBSTITUTED HYDANTOIN RACEMASE, DNA ENCODING THE SAME, RECOMBINANT DNA, TRANSFORMED CELL, AND PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE N-CARBAMYLAMINO ACID OR OPTICALLY ACTIVE AMINO ACID Kaneka Corporation (JP) 2007-11-07 EP disclosed
US-20060205030-A1 DNA for encoding D-hydantoin hydrolases, DNA for encoding N-carbamyl-D-amino acid hydrolases, recombinant DNA containing the genes, cells transformed with the recombinant DNA, methods for producing proteins utilizing the transformed cells and methods for producing D-amino acids AJINOMOTO CO., INC. (JP) 2006-09-14 US disclosed
US-20030148472-A1 DNA for encoding D-hydantoin hydrolases, DNA for encoding N-carbamyl-D-amino acid hydrolases, recombinant DNA containing the genes, cells transformed with the recombinant DNA, methods for producing proteins utilizing the transformed cells and methods for producing D-amino acids AJINOMOTO CO., INC. (JP) 2003-08-07 US disclosed
US-20030113880-A1 DNA for encoding D-hydantoin hydrolases, DNA for encoding N-carbamyl-D-amino acid hydrolases, recombinant DNA containing the genes, cells transformed with the recombinant DNA, methods for producing proteins utilizing the transformed cells and methods for producing D-amino acids AJINOMOTO CO., INC. (JP) 2003-06-19 US disclosed
EP-1275723-A1 Recombinant D-hydantoin hydrolases and N-carbamyl-D-amino acid hydrolases, and DNA encoding them; uses thereof for producing D-amino acids Ajinomoto Co., Inc. (JP) 2003-01-15 EP disclosed
EP-0628637-B1 PROCESS FOR PRODUCING D-ALPHA-AMINO ACIDS KANEGAFUCHI CHEMICAL IND (JP) 2001-06-13 EP disclosed
US-5902736-A USING DECARBAMYLASE FROM COMAMONAS, ALCALIGENES, RHIZOBIUM, BLASTOBACTER, SPOROSARCINA, AND BRADYRHYZOBIUM SPECIES IN AQUEOUS MEDIUM; AS CHEMICAL INTERMEDIATES FOR SEMISYNTHETIC PENICILLIN AND CEPHALOSPORIN KANEGAFUCHI CHEMICAL INDUSTRY CO., LTD. (JP) 1999-05-11 US disclosed
US-5863785-A PROTEINS KANEGAFUCHI CHEMICAL INDUSTRY CO., LTD. (JP) 1999-01-26 US disclosed
US-5714355-A BIOLOGICALLY PURE CULTURE OF MUTANT MICROORGANISM DEGUSSA AKTIENGESELLSCHAFT (DE) 1998-02-03 US disclosed
EP-0628637-A1 PROCESS FOR PRODUCING D-$g(a)-AMINO ACID Kanegafuchi Chemical Industry Co., Ltd. (JP) 1994-12-14 EP disclosed
US-4418146-A CBS 303.80 OR CBS 363.50 THERMOPHILIC, NON-SPORULATING STRAINS BASF AKTIENGESELLSCHAFT (DE) 1983-11-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030113880-A1 DNA for encoding D-hydantoin hydrolases, DNA for encoding N-carbamyl-D-amino acid hydrolases, recombinant DNA containing the genes, cells transformed with the recombinant DNA, methods for producing proteins utilizing the transformed cells and methods for producing D-amino acids DCTD, DDAH1, AHCY SLC7A5 1031/4885PTGS1 2334/4885ALPI 489/4885
US-20060205030-A1 DNA for encoding D-hydantoin hydrolases, DNA for encoding N-carbamyl-D-amino acid hydrolases, recombinant DNA containing the genes, cells transformed with the recombinant DNA, methods for producing proteins utilizing the transformed cells and methods for producing D-amino acids DCTD, DDAH1, AHCY SLC7A5 1031/4885PTGS1 2334/4885ALPI 489/4885
US-20030148472-A1 DNA for encoding D-hydantoin hydrolases, DNA for encoding N-carbamyl-D-amino acid hydrolases, recombinant DNA containing the genes, cells transformed with the recombinant DNA, methods for producing proteins utilizing the transformed cells and methods for producing D-amino acids DCTD, DDAH1, AHCY SLC7A5 1031/4885PTGS1 2334/4885ALPI 489/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.