Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.49 |
| ▸ | CTSD | P07339 | 14/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7538302 | 0.89 | BACE1 (0.51) | BACE1CTSDPRMT5WDR77HPGD | |
| SCHEMBL7531658 | 0.89 | BACE1 (0.51) | BACE1CTSDPRMT5WDR77HPGD | |
| SCHEMBL7533881 | 0.89 | BACE1 (0.51) | BACE1CTSDPRMT5WDR77HPGD | |
| SCHEMBL10121022 | 0.87 | BACE1 (0.45) | BACE1CTSDPRMT5WDR77HPGD | |
| SCHEMBL10121026 | 0.85 | BACE1 (0.50) | BACE1CTSD | |
| SCHEMBL10121006 | 0.82 | BACE1 (0.44) | BACE1CTSDPRMT5WDR77 | |
| SCHEMBL10121004 | 0.81 | BACE1 (0.46) | BACE1CTSD | |
| SCHEMBL10121023 | 0.81 | BACE1 (0.47) | BACE1CTSD | |
| SCHEMBL10121024 | 0.81 | BACE1 (0.47) | BACE1CTSD | |
| SCHEMBL10121020 | 0.80 | KDM4E (0.44) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178513-B2 | Heterocyclic aspartyl protease inhibitors | SCHERING CORPORATION (US) | 2012-05-15 | — | — | US | disclosed |