Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.45 |
| ▸ | CTSD | P07339 | 14/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7538345 | 0.90 | BACE1 (0.46) | BACE1CTSDMEN1HPGDKMT2A | |
| SCHEMBL7537566 | 0.90 | BACE1 (0.46) | BACE1CTSDMEN1HPGDKMT2A | |
| SCHEMBL10120997 | 0.87 | BACE1 (0.49) | BACE1CTSDHPGDPRMT5WDR77 | |
| SCHEMBL10121023 | 0.81 | BACE1 (0.47) | BACE1CTSD | |
| SCHEMBL10121024 | 0.81 | BACE1 (0.47) | BACE1CTSD | |
| SCHEMBL10121020 | 0.80 | KDM4E (0.44) | BACE1CTSD | |
| SCHEMBL8198551 | 0.80 | BACE1 (0.43) | BACE1CTSDHPGD | |
| SCHEMBL13054411 | 0.80 | BACE1 (0.43) | BACE1CTSDHPGD | |
| SCHEMBL2965484 | 0.80 | BACE1 (0.43) | BACE1CTSDHPGD | |
| SCHEMBL2965482 | 0.80 | BACE1 (0.43) | BACE1CTSDHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178513-B2 | Heterocyclic aspartyl protease inhibitors | SCHERING CORPORATION (US) | 2012-05-15 | — | — | US | disclosed |