Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.51 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL419483 | 0.95 | HTT (0.60) | HTTMEN1KMT2AEPHX2PDK1 | |
| SCHEMBL10123473 | 0.88 | PDK1 (0.62) | HTTMEN1KMT2APDK1PDK2 | |
| SCHEMBL10123506 | 0.84 | EPHX2 (0.67) | KMT2AEPHX2NPC1RAB9AMAPT | |
| SCHEMBL418319 | 0.83 | PDK1 (0.65) | HTTMEN1KMT2APDK1PDK2 | |
| SCHEMBL13993361 | 0.83 | RAB9A (0.61) | HTTMEN1KMT2APDK1PDK2 | |
| SCHEMBL10123510 | 0.81 | KMT2A (0.59) | HTTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL10123543 | 0.81 | MEN1 (0.59) | HTTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL13993503 | 0.80 | KMT2A (0.62) | HTTMEN1KMT2AEPHX2RAB9A | |
| SCHEMBL12061944 | 0.79 | LMNA (0.73) | HTTEPHX2PDK1PDK2PDK3 | |
| SCHEMBL10123470 | 0.79 | MAPT (0.64) | HTTMEN1KMT2AEPHX2PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012060820-A1 | SULFONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES | SIGA TECHNOLOGIES, INC. (US) | 2012-05-10 | — | — | WO | disclosed |