Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 4/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 4/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10123569 | 0.78 | ALDH1A1 (0.45) | PDK1PDK2PDK3PDK4MAPT | |
| SCHEMBL10123574 | 0.73 | GAA (0.40) | PDK1PDK2PDK3PDK4MAPT | |
| SCHEMBL10123576 | 0.73 | GAA (0.34) | MAPTHTTGAALMNAKMT2A | |
| SCHEMBL10122312 | 0.73 | MAPT (0.70) | PDK1PDK2PDK3PDK4MAPT | |
| SCHEMBL10123535 | 0.72 | ABCB1 (0.35) | MAPTHTTGAALMNAALDH1A1 | |
| SCHEMBL10123572 | 0.70 | KDM4E (0.42) | MAPTHTTGAALMNAALDH1A1 | |
| SCHEMBL10123578 | 0.70 | GAA (0.42) | PDK1PDK2PDK3PDK4MAPT | |
| SCHEMBL10123534 | 0.70 | GAA (0.43) | MAPTHTTGAAALDH1A1MEN1 | |
| SCHEMBL10123461 | 0.69 | MEN1 (0.38) | MAPTHTTGAALMNAALDH1A1 | |
| SCHEMBL5211507 | 0.68 | MEN1 (0.61) | PDK1PDK2PDK3PDK4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012060820-A1 | SULFONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES | SIGA TECHNOLOGIES, INC. (US) | 2012-05-10 | — | — | WO | disclosed |