Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.35 |
| ▸ | IL2 | P60568 | 9/20 | 0.35 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8234343 | 0.89 | IL2 (0.38) | RORCSTIM1ORAI1MEN1KMT2A | |
| SCHEMBL3096594 | 0.85 | STIM1 (0.44) | RORCSTIM1ORAI1MEN1KMT2A | |
| SCHEMBL14373602 | 0.85 | MEN1 (0.39) | RORCSTIM1ORAI1MEN1KMT2A | |
| SCHEMBL3103841 | 0.83 | MEN1 (0.40) | RORCSTIM1ORAI1MEN1KMT2A | |
| SCHEMBL11940274 | 0.83 | IL2 (0.41) | RORCSTIM1ORAI1MEN1KMT2A | |
| SCHEMBL648215 | 0.83 | MEN1 (0.40) | RORCMEN1KMT2AIL2NPC1 | |
| SCHEMBL647154 | 0.82 | RAB9A (0.43) | RORCMEN1KMT2AIL2CRACR2A | |
| SCHEMBL646344 | 0.82 | RXRA (0.44) | RORCSTIM1ORAI1MEN1KMT2A | |
| SCHEMBL647102 | 0.82 | IL2 (0.41) | RORCMEN1KMT2AIL2CRACR2A | |
| SCHEMBL13099813 | 0.81 | RORC (0.37) | RORCSTIM1ORAI1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119643-B2 | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2012-02-21 | — | — | US | disclosed |