Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | GAA | P10253 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5527258 | 0.88 | MAPT (0.74) | MAPTKDM4EGAAALDH1A1KMT2A | |
| SCHEMBL4070839 | 0.86 | ALDH1A1 (0.84) | MAPTKDM4EGAAALDH1A1KMT2A | |
| SCHEMBL3300404 | 0.84 | ALDH1A1 (0.84) | MAPTGAAALDH1A1KMT2ALMNA | |
| SCHEMBL5432715 | 0.82 | MAPT (1.00) | MAPTKDM4EGAAALDH1A1KMT2A | |
| SCHEMBL17131816 | 0.81 | TSHR (0.77) | MAPTKDM4EGAAALDH1A1KMT2A | |
| SCHEMBL165282 | 0.80 | KMT2A (0.69) | MAPTKDM4EGAAALDH1A1KMT2A | |
| SCHEMBL9095171 | 0.80 | GAA (0.59) | MAPTKDM4EGAAALDH1A1KMT2A | |
| SCHEMBL8649261 | 0.79 | KMT2A (0.71) | MAPTALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL4655484 | 0.79 | USP2 (0.71) | MAPTKDM4EGAAALDH1A1KMT2A | |
| SCHEMBL12491151 | 0.78 | ALDH1A1 (0.67) | MAPTKDM4EGAAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110574-B2 | Derivatives of 4-aminopiperidine and their use as a medicament | IPSEN PHARMA S.A.S. (FR) | 2012-02-07 | — | — | US | disclosed |