Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.69 |
| ▸ | MEN1 | O00255 | 5/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | TP53 | P04637 | 3/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | RECQL | P46063 | 1/20 | 0.69 |
| ▸ | F13A1 | P00488 | 1/20 | 0.65 |
| ▸ | TGM2 | P21980 | 1/20 | 0.65 |
| ▸ | TGM1 | P22735 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5527258 | 0.86 | MAPT (0.74) | KMT2AMEN1MAPTALDH1A1KDM4E | |
| SCHEMBL4070839 | 0.84 | ALDH1A1 (0.84) | KMT2AMEN1MAPTALDH1A1KDM4E | |
| SCHEMBL3300404 | 0.83 | ALDH1A1 (0.84) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL12491151 | 0.83 | ALDH1A1 (0.67) | KMT2AMEN1MAPTALDH1A1KDM4E | |
| SCHEMBL17131816 | 0.82 | TSHR (0.77) | KMT2AMEN1MAPTALDH1A1KDM4E | |
| SCHEMBL3456157 | 0.81 | PDK1 (0.74) | KMT2AMEN1MAPTALDH1A1KDM4E | |
| SCHEMBL22055735 | 0.81 | F13A1 (0.97) | KMT2AMEN1MAPTALDH1A1KDM4E | |
| SCHEMBL8649261 | 0.81 | KMT2A (0.71) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL5432715 | 0.81 | MAPT (1.00) | KMT2AMEN1MAPTALDH1A1KDM4E | |
| SCHEMBL31195227 | 0.81 | ALDH1A1 (0.72) | KMT2AMEN1MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611777-A1 | 4- { [ ( PYRIDIN- 3 - YL -METHYL) AMINOCARBONYL]AMINO} BENZENE - SULFONE DERIVATIVES AS NAMPT INHIBITORS FOR THERAPY OF DISEASES SUCH AS CANCER | Forma TM, LLC. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012031196-A1 | 4- { [ ( PYRIDIN- 3 - YL -METHYL) AMINOCARBONYL] AMINO} BENZENE - SULFONE DERIVATIVES AS NAMPT INHIBITORS FOR THERAPY OF DISEASES SUCH AS CANCER | FORMA THERAPEUTICS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |