Sugi Predict

Sugi Predict / Compounds / SCHEMBL10125807

SCHEMBL10125807

SCHEMBL10125807

Cc1cc2nc(-c3ccccc3)c(-c3ccc(-c4ccc(-c5nc6ccccc6o5)cc4)cc3)nc2cc1C

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 8/20 0.55
▸ RAB9A P51151 6/20 0.55
▸ KDM4E B2RXH2 6/20 0.55
▸ HPGD P15428 6/20 0.55
▸ SMN1; SMN2 Q16637 6/20 0.55
▸ CASP3 P42574 3/20 0.55
▸ SENP7 Q9BQF6 3/20 0.55
▸ SENP6 Q9GZR1 3/20 0.55
▸ SENP8 Q96LD8 2/20 0.55
▸ POLB P06746 1/20 0.55
▸ MEN1 O00255 2/20 0.54
▸ KMT2A Q03164 2/20 0.54
▸ ATM Q13315 1/20 0.54
▸ ALDH1A1 P00352 6/20 0.52
▸ HSD17B10 Q99714 4/20 0.52
▸ MAPT P10636 3/20 0.52
▸ HCRTR1 O43613 2/20 0.52
▸ USP2 O75604 2/20 0.52
▸ TSHR P16473 1/20 0.52
▸ MAPK1 P28482 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10125993 0.97 NPC1 (0.56) NPC1RAB9AKDM4EHPGDSMN1; SMN2
SCHEMBL10315206 0.90 NPC1 (0.48) NPC1RAB9AKDM4EHPGDSMN1; SMN2
SCHEMBL10125862 0.89 SMN1; SMN2 (0.55) NPC1RAB9AKDM4EHPGDSMN1; SMN2
SCHEMBL10315437 0.89 NPC1 (0.48) NPC1RAB9AKDM4EHPGDSMN1; SMN2
SCHEMBL23606298 0.88 NPC1 (0.63) NPC1RAB9AKDM4EHPGDSMN1; SMN2
SCHEMBL10125829 0.88 NPC1 (0.63) NPC1RAB9AKDM4EHPGDSMN1; SMN2
SCHEMBL652573 0.88 NPC1 (0.63) NPC1RAB9AKDM4EHPGDSMN1; SMN2
SCHEMBL10125830 0.88 NPC1 (0.63) NPC1RAB9AKDM4EHPGDSMN1; SMN2
SCHEMBL10125896 0.88 NPC1 (0.63) NPC1RAB9AKDM4EHPGDSMN1; SMN2
SCHEMBL10125952 0.87 NPC1 (0.55) NPC1RAB9AKDM4EHPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8119259-B2 Quinoxaline derivative, and light-emitting element and electronic device using the same SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2012-02-21 — — US disclosed
US-8119259-B2 Quinoxaline derivative, and light-emitting element and electronic device using the same SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2012-02-21 — — US disclosed
US-20090140642-A1 Quinoxaline Derivative, and Light-Emitting Element and Electronic Device Using the Same SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2009-06-04 — — US disclosed
US-20090140642-A1 Quinoxaline Derivative, and Light-Emitting Element and Electronic Device Using the Same SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2009-06-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090140642-A1 Quinoxaline Derivative, and Light-Emitting Element and Electronic Device Using the Same NDUFA11, NDUFA9, NDUFA12 NPC1 4763/4885RAB9A 1141/4885KDM4E 2216/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.