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Sugi Predict / Targets / NDUFA9

NDUFA9

NADH dehydrogenase [ubiquinone] 1 alpha subco · Q16795 · NDUFA9 on Sugi Atlas →

1,506 patent compounds predicted against NDUFA9, 861 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL15258558 SCHEMBL15258558 0.76 8/20
SCHEMBL12362713 SCHEMBL12362713 0.77 7/20
SCHEMBL15080621 SCHEMBL15080621 0.77 7/20
SCHEMBL12362702 SCHEMBL12362702 0.73 7/20
SCHEMBL14351066 SCHEMBL14351066 0.69 7/20
SCHEMBL12226742 SCHEMBL12226742 0.61 7/20
SCHEMBL12362734 SCHEMBL12362734 0.60 6/20
SCHEMBL12362700 SCHEMBL12362700 0.57 6/20
SCHEMBL13973668 SCHEMBL13973668 0.47 6/20
SCHEMBL16316892 SCHEMBL16316892 0.47 6/20
Auraptene Auraptene (SCHEMBL2535029) 1.00 5/20
Auraptene Auraptene (SCHEMBL2535034) 1.00 5/20
SCHEMBL12362712 SCHEMBL12362712 0.80 5/20
SCHEMBL14437596 SCHEMBL14437596 0.57 5/20
SCHEMBL14437626 SCHEMBL14437626 0.57 5/20
SCHEMBL14515244 SCHEMBL14515244 0.57 5/20
SCHEMBL13743063 SCHEMBL13743063 0.43 5/20
SCHEMBL11456503 SCHEMBL11456503 0.71 4/20
SCHEMBL11456504 SCHEMBL11456504 0.71 4/20
SCHEMBL11457189 SCHEMBL11457189 0.69 4/20

Clinical trials — most relevant to NDUFA9 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease PHASE3COMPLETED
A Study of Efficacy, Safety and Tolerability of Idebenone in the Treatment of Friedreich's Ataxia (FRDA) Patients PHASE3COMPLETED
Effect of Montelukast Versus Co Enzyme in Sepsis PHASE2/PHASE3COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) PHASE3WITHDRAWN
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder PHASE2WITHDRAWN
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease PHASE2COMPLETED
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy PHASE2ACTIVE_NOT_RECRUITING
Parkinson's Disease Treatment With Coenzyme Q10 PHASE2COMPLETED
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) PHASE1/PHASE2NOT_YET_RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Ubiquinol (Reduced COQ10) for Patients With Sepsis PHASE2COMPLETED
Mini-MARVEL - Mitochondrial Antioxidant Therapy in Ulcerative Colitis PHASE2WITHDRAWN
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? PHASE1UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
The Natural History of Mitochondrial Diseases nanRECRUITING
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability. nanUNKNOWN
Natural History in Primary Mitochondrial Myopathies nanRECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection nanCOMPLETED
Pharmacokinetic Study on Three Formulations of Coenzyme Q10 With Different Carriers nanUNKNOWN
Diagnostic Odyssey Survey 2 nanCOMPLETED
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders nanCOMPLETED
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy nanRECRUITING
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases nanRECRUITING
Coenzyme Q10 Plus NADH Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis nanCOMPLETED
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip nanCOMPLETED
Assessment of Follicular Fluid Level of Coenzyme Q10 in Women Undergoing ICSI nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a NDUFA9 binder may also engage these)

ProteinNameSimilarity
Q0MQB3 — 1.000 Q0MQB3 →
Q0MQB4 — 1.000 Q0MQB4 →
P0CB81 — 1.000 P0CB81 →
Q5BK63 — 1.000 Q5BK63 →
P0CB82 — 1.000 P0CB82 →
P34943 — 1.000 P34943 →
Q9DC69 — 1.000 Q9DC69 →
Q9SK66 — 0.995 Q9SK66 →
P25284 — 0.984 P25284 →
P0CB89 — 0.972 P0CB89 →
Q0MQB6 — 0.972 Q0MQB6 →
Q0MQB7 — 0.972 Q0MQB7 →
P87172 — 0.971 P87172 →
Q6DCP1 — 0.970 Q6DCP1 →
Q99LC3 — 0.969 Q99LC3 →
Q3YA36 — 0.969 Q3YA36 →
P0CB90 — 0.968 P0CB90 →
Q0IH73 — 0.968 Q0IH73 →
A8E657 — 0.968 A8E657 →
Q58H57 — 0.968 Q58H57 →
Q5RAP5 — 0.968 Q5RAP5 →
Q8TB40 — 0.968 Q8TB40 →
Q9UDR5 — 0.968 Q9UDR5 →
Q4R0H9 — 0.967 Q4R0H9 →
Q9Y394 — 0.967 Q9Y394 →
Q80ZF7 — 0.967 Q80ZF7 →
Q8VCH7 — 0.967 Q8VCH7 →
Q9ZVN2 — 0.967 Q9ZVN2 →
Q7T2D1 — 0.967 Q7T2D1 →
Q561S0 — 0.967 Q561S0 →