Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 4/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.57 |
| ▸ | DRD3 | P35462 | 2/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10126794 | 1.00 | ADRA1A (0.57) | ADRA1ACYP2D6CYP2C19LMNAHIF1A | |
| SCHEMBL6679827 | 0.81 | POLB (0.53) | ADRA1ACYP2D6CYP2C19LMNAHIF1A | |
| SCHEMBL11299290 | 0.80 | ALDH1A1 (0.60) | ADRA1ACYP2D6CYP2C19LMNAHIF1A | |
| SCHEMBL4382670 | 0.79 | LMNA (0.65) | ADRA1ACYP2D6CYP2C19LMNAHIF1A | |
| Hydrochloric Acid SCHEMBL30527155 | 0.78 | ALDH1A1 (0.60) | ADRA1ACYP2D6CYP2C19LMNAHIF1A | |
| SCHEMBL965329 | 0.78 | ADRA1A (0.57) | ADRA1ACYP2D6CYP2C19LMNAHIF1A | |
| SCHEMBL968204 | 0.78 | ADRA1A (0.57) | ADRA1ACYP2D6CYP2C19LMNAHIF1A | |
| SCHEMBL965331 | 0.78 | ADRA1A (0.57) | ADRA1ACYP2D6CYP2C19LMNAHIF1A | |
| SCHEMBL16784192 | 0.77 | LMNA (0.68) | ADRA1ACYP2D6CYP2C19LMNAHIF1A | |
| SCHEMBL8644590 | 0.77 | LMNA (0.68) | ADRA1ACYP2D6CYP2C19LMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163758-B2 | Phenyl substituted pyrazinoylguanidine sodium channel blockers possessing beta agonist activity | PARION SCIENCES, INC. (US) | 2012-04-24 | — | — | US | disclosed |