Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.50 |
| ▸ | PDE5A | O76074 | 2/20 | 0.49 |
| ▸ | ELANE | P08246 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725521 | 0.82 | MAOB (0.48) | HTTSMN1; SMN2MAOBEGFRERBB2 | |
| SCHEMBL6471210 | 0.80 | EGFR (0.50) | L3MBTL1SMN1; SMN2MAOBEGFRERBB2 | |
| SCHEMBL28023475 | 0.79 | PDE5A (0.59) | PDE5AELANEL3MBTL1HRH4ALDH1A1 | |
| SCHEMBL11009131 | 0.78 | TSHR (0.52) | PIN1PDE5AL3MBTL1STAT3HTT | |
| Hydrochloric Acid SCHEMBL28023495 | 0.78 | PDE5A (0.57) | PDE5AELANEL3MBTL1HRH4ALDH1A1 | |
| SCHEMBL8682782 | 0.78 | TSHR (0.46) | METAP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL578063 | 0.77 | PIN1 (0.49) | PIN1PDE5AL3MBTL1SMN1; SMN2MAOA | |
| SCHEMBL1639465 | 0.77 | PIN1 (0.49) | PIN1PDE5AL3MBTL1SMN1; SMN2MAOA | |
| SCHEMBL10615700 | 0.76 | PIN1 (0.50) | PIN1PDE5AELANEL3MBTL1CLK4 | |
| SCHEMBL28430438 | 0.76 | CYP3A4 (0.49) | MAOAMAOBACHEEGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268623-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |