Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 7/20 | 0.38 |
| ▸ | CTSS | P25774 | 6/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10129167 | 0.88 | MEN1 (0.43) | MEN1GAAKMT2ATDP1CKS1B | |
| SCHEMBL1003435 | 0.83 | MEN1 (0.61) | MEN1GAAKMT2ATDP1CTSK | |
| SCHEMBL18281226 | 0.83 | MEN1 (0.61) | MEN1GAAKMT2ATDP1CTSK | |
| SCHEMBL2850443 | 0.83 | MEN1 (0.61) | MEN1GAAKMT2ATDP1CTSK | |
| SCHEMBL20209500 | 0.82 | MEN1 (0.59) | MEN1GAAKMT2ATDP1CTSK | |
| SCHEMBL10935584 | 0.80 | MEN1 (0.58) | MEN1GAAKMT2ATDP1FOLH1 | |
| SCHEMBL16945135 | 0.80 | MEN1 (0.58) | MEN1GAAKMT2ATDP1FOLH1 | |
| SCHEMBL10164405 | 0.78 | MEN1 (0.55) | MEN1GAAKMT2ATDP1FOLH1 | |
| SCHEMBL21518411 | 0.77 | MEN1 (0.54) | MEN1GAAKMT2ACTSKCTSS | |
| SCHEMBL3183889 | 0.77 | MEN1 (0.54) | MEN1GAAKMT2ACTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130274254-A1 | INHIBITORS OF CYTOCHROME P450 (CYP3A4) | GILEAD SCIENCES, INC. (US) | 2013-10-17 | — | — | US | disclosed |
| WO-2012088178-A1 | INHIBITORS OF CYTOCHROME P450 (CYP3A4) | GILEAD SCIENCES, INC. (US) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274254-A1 | INHIBITORS OF CYTOCHROME P450 (CYP3A4) | CYP3A43, CYP3A7, CYP3A4 | MEN1 4753/4885GAA 230/4885KMT2A 4099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.