Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10129164 | 0.88 | MEN1 (0.50) | MEN1KMT2AGAATDP1MALT1 | |
| SCHEMBL10164404 | 0.79 | MEN1 (0.47) | MEN1KMT2AGAATDP1CA12 | |
| SCHEMBL20366319 | 0.79 | MEN1 (0.47) | MEN1KMT2AGAATDP1CA12 | |
| SCHEMBL12417725 | 0.78 | MEN1 (0.43) | MEN1KMT2AGAATDP1CA12 | |
| SCHEMBL20366152 | 0.78 | KLK5 (0.45) | MEN1KMT2AGAATDP1CA12 | |
| SCHEMBL15159978 | 0.78 | MEN1 (0.51) | MEN1KMT2AGAATDP1CA12 | |
| SCHEMBL20556183 | 0.78 | MEN1 (0.51) | MEN1KMT2AGAATDP1CA12 | |
| SCHEMBL11919227 | 0.76 | MEN1 (0.50) | MEN1KMT2AGAATDP1CA12 | |
| SCHEMBL20366165 | 0.76 | MEN1 (0.42) | MEN1KMT2AGAATDP1CA12 | |
| SCHEMBL30679020 | 0.75 | MEN1 (0.43) | MEN1KMT2AGAATDP1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130274254-A1 | INHIBITORS OF CYTOCHROME P450 (CYP3A4) | GILEAD SCIENCES, INC. (US) | 2013-10-17 | — | — | US | disclosed |
| WO-2012088178-A1 | INHIBITORS OF CYTOCHROME P450 (CYP3A4) | GILEAD SCIENCES, INC. (US) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274254-A1 | INHIBITORS OF CYTOCHROME P450 (CYP3A4) | CYP3A43, CYP3A7, CYP3A4 | MEN1 4753/4885KMT2A 4099/4885GAA 230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.