Sugi Predict

Sugi Predict / Compounds / SCHEMBL10129374

SCHEMBL10129374

SCHEMBL10129374

CC(C)(C)c1cn(S(C)(=O)=O)c2ccccc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTR6 P50406 9/20 0.50
▸ LMNA P02545 1/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ KDM4E B2RXH2 1/20 0.40
▸ UBE2N P61088 1/20 0.40
▸ HTR3A P46098 4/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ PLK1 P53350 1/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ FABP4 P15090 1/20 0.38
▸ CA12 O43570 1/20 0.38
▸ CA2 P00918 1/20 0.38
▸ CA9 Q16790 1/20 0.38
▸ HTR1A P08908 1/20 0.38
▸ DRD2 P14416 1/20 0.38
▸ HTR1D P28221 1/20 0.38
▸ HTR1B P28222 1/20 0.38
▸ HTR1F P30939 1/20 0.38
▸ HTR7 P34969 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10129379 0.87 HTR6 (0.43) HTR6LMNASMN1; SMN2KDM4EUBE2N
SCHEMBL18125259 0.83 HTR6 (0.61) HTR6LMNASMN1; SMN2KDM4EUBE2N
SCHEMBL22339784 0.80 KDM4E (0.66) HTR6LMNASMN1; SMN2KDM4EUBE2N
SCHEMBL2692814 0.77 HTR6 (0.59) HTR6LMNASMN1; SMN2KDM4EUBE2N
SCHEMBL12718451 0.76 HTR6 (0.50) HTR6LMNASMN1; SMN2KDM4EUBE2N
SCHEMBL10819615 0.76 HTR6 (0.61) HTR6HTR1ADRD2HTR1DHTR1B
SCHEMBL15143081 0.75 HTR6 (0.41) HTR6LMNASMN1; SMN2HTR3AHTR1A
SCHEMBL6287898 0.75 HTR6 (0.53) HTR6LMNASMN1; SMN2KDM4EUBE2N
SCHEMBL8499521 0.75 HTR6 (0.53) HTR6LMNASMN1; SMN2KDM4EUBE2N
SCHEMBL6181975 0.75 HTR6 (0.53) HTR6LMNASMN1; SMN2KDM4EUBE2N

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160074381-A1 MODULATORS OF CELLULAR ADHESION SARCODE BIOSCIENCE INC. (US) 2016-03-17 — — US disclosed
US-9248126-B2 Modulators of cellular adhesion SARCODE BIOSCIENCE INC. (US) 2016-02-02 — — US disclosed
US-9216174-B2 Modulators of cellular adhesion SARCODE BIOSCIENCE INC. (US) 2015-12-22 — — US disclosed
US-20140066476-A1 MODULATORS OF CELLULAR ADHESION SARCODE BIOSCIENCE INC. (US) 2014-03-06 — — US disclosed
US-20140051675-A1 MODULATORS OF CELLULAR ADHESION SARCODE BIOSCIENCE INC. (US) 2014-02-20 — — US disclosed
US-20120035154-A1 Modulators of Cellular Adhesion SARcode Bioscience, Inc. (US) 2012-02-09 — — US disclosed
US-8071617-B2 Modulators of cellular adhesion SARCODE BIOSCIENCE INC. (US) 2011-12-06 — — US disclosed
US-7989626-B2 Modulators of cellular adhesion SAR code Corporation (US) 2011-08-02 — — US disclosed
US-20110124669-A1 Modulators of Cellular Adhesion SARCODE CORPORATION (US) 2011-05-26 — — US disclosed
US-20110124625-A1 Modulators of Cellular Adhesion SARCODE CORPORATION (US) 2011-05-26 — — US disclosed
US-7928122-B2 Modulators of cellular adhesion SARCODE CORPORATION (US) 2011-04-19 — — US disclosed
US-7790743-B2 Modulators of cellular adhesion SARCODE CORPORATION (US) 2010-09-07 — — US disclosed
US-7745460-B2 Modulators of cellular adhesion SARCODE CORPORATION (US) 2010-06-29 — — US disclosed
US-20100093693-A1 MODULATORS OF CELLULAR ADHESION BAUSCH + LOMB IRELAND LIMITED (IE) 2010-04-15 — — US disclosed
US-20080182839-A1 MODULATORS OF CELLULAR ADHESION SUNESIS PHARMACEUTICALS, INC. (US) 2008-07-31 — — US disclosed
US-20080176896-A1 Modulators of cellular adhesion BAUSCH + LOMB IRELAND LIMITED (IE) 2008-07-24 — — US disclosed
US-7314938-B2 Immune and/or inflammatory disorders; autoimmune disorders; disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1); antagonize CD11/CD18 receptors associated with leukocytes. SUNESIS PHARMACEUTICALS, INC. (US) 2008-01-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140066476-A1 MODULATORS OF CELLULAR ADHESION ITGB1, VCAM1, ITGB8 HTR6 2774/4885LMNA 1395/4885SMN1; SMN2 2217/4885
US-20080176896-A1 Modulators of cellular adhesion ITGB1, VCAM1, ITGB8 HTR6 2774/4885LMNA 1395/4885SMN1; SMN2 2217/4885
US-20140051675-A1 MODULATORS OF CELLULAR ADHESION ITGB1, VCAM1, ITGB8 HTR6 2774/4885LMNA 1395/4885SMN1; SMN2 2217/4885
US-20100093693-A1 MODULATORS OF CELLULAR ADHESION ITGB1, VCAM1, ITGB8 HTR6 2835/4885LMNA 1384/4885SMN1; SMN2 2229/4885
US-20110124625-A1 Modulators of Cellular Adhesion ITGB1, VCAM1, ITGB8 HTR6 2774/4885LMNA 1395/4885SMN1; SMN2 2217/4885
US-20160074381-A1 MODULATORS OF CELLULAR ADHESION ITGB1, VCAM1, ITGB8 HTR6 2774/4885LMNA 1395/4885SMN1; SMN2 2217/4885
US-20110124669-A1 Modulators of Cellular Adhesion ITGB1, VCAM1, ITGB8 HTR6 2774/4885LMNA 1395/4885SMN1; SMN2 2217/4885
US-20120035154-A1 Modulators of Cellular Adhesion ITGB1, VCAM1, ITGB8 HTR6 2774/4885LMNA 1395/4885SMN1; SMN2 2217/4885
US-20080182839-A1 MODULATORS OF CELLULAR ADHESION ITGB1, VCAM1, ITGB8 HTR6 2832/4885LMNA 1380/4885SMN1; SMN2 2288/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.