Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 9/20 | 0.53 |
| ▸ | HTR3A | P46098 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL788310 | 0.81 | LMNA (0.40) | HTR6LMNASMN1; SMN2KDM4EUBE2N | |
| SCHEMBL2692814 | 0.79 | HTR6 (0.59) | HTR6HTR3ALMNASMN1; SMN2KDM4E | |
| SCHEMBL6181975 | 0.78 | HTR6 (0.53) | HTR6HTR3ALMNASMN1; SMN2KDM4E | |
| SCHEMBL8499521 | 0.78 | HTR6 (0.53) | HTR6HTR3ALMNASMN1; SMN2KDM4E | |
| SCHEMBL3615167 | 0.77 | KDM4E (0.68) | HTR6LMNASMN1; SMN2KDM4EUBE2N | |
| SCHEMBL7671291 | 0.75 | HTR6 (0.66) | HTR6AGTR1 | |
| SCHEMBL12718451 | 0.75 | HTR6 (0.50) | HTR6HTR3ALMNASMN1; SMN2KDM4E | |
| SCHEMBL6182319 | 0.75 | HTR6 (0.50) | HTR6HTR3ALMNASMN1; SMN2KDM4E | |
| SCHEMBL1418230 | 0.75 | KDM4E (0.66) | HTR6LMNASMN1; SMN2KDM4EUBE2N | |
| SCHEMBL10129374 | 0.75 | HTR6 (0.50) | HTR6HTR3ALMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6881727-B2 | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same | SHIONOGI & CO., LTD. (JP) | 2005-04-19 | — | — | US | claimed |
| EP-1486207-A2 | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same | SHIONOGI & CO., LTD. (JP) | 2004-12-15 | — | — | EP | claimed |
| US-20030225043-A1 | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same | SHIONOGI & CO., LTD. | 2003-12-04 | — | — | US | claimed |
| US-20030139379-A1 | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same | SHIONOGI & CO., LTD. | 2003-07-24 | — | — | US | claimed |
| EP-0950656-A1 | SULFONATED AMINO ACID DERIVATIVES AND METALLOPROTEINASE INHIBITORS CONTAINING THE SAME | SHIONOGI & CO., LTD. (JP) | 1999-10-20 | — | — | EP | claimed |
| US-6919375-B1 | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same | SHIONOGI & CO., LTD. (JP) | 2005-07-19 | — | — | US | disclosed |
| US-6881727-B2 | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same | SHIONOGI & CO., LTD. (JP) | 2005-04-19 | — | — | US | disclosed |
| US-6838483-B2 | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same | SHIONOGI & CO., LTD. (JP) | 2005-01-04 | — | — | US | disclosed |
| EP-1486207-A2 | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same | SHIONOGI & CO., LTD. (JP) | 2004-12-15 | — | — | EP | disclosed |
| US-20030225043-A1 | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same | SHIONOGI & CO., LTD. | 2003-12-04 | — | — | US | disclosed |
| US-20030139379-A1 | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same | SHIONOGI & CO., LTD. | 2003-07-24 | — | — | US | disclosed |
| US-6441021-B1 | TYPE-IV COLLAGENASE INHIBITORS | SHIONOGI & CO., LTD. (JP) | 2002-08-27 | — | — | US | disclosed |
| US-6235768-B1 | OSTEOPOROSIS; RHEUMATIC DISORDERS; ANTITUMOR AGENTS | SHIONOGI & CO., LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| US-6207698-B1 | FOR THERAPY OF OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, CORNEAL ULCERATION, PERIODONTITIS, METASTASIS AND INVASION OF TUMOR, AND VIRUS INFECTION | SHIONOGI & CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| US-6150394-A | 1-(INDOLYL),1-((PHENYL)PHENYL)SULFONAMIDO)ACETIC ACID OR N-HYDROXYACETAMIDE AND DERIVATIVES; ENZYME INHIBITORS E.G., GELATINASE, STROMELYSIN, COLLAGENASE; OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, CORNEAL ULCERATION, PERIODONTITIS, HIV | SHIONOGI & CO., LTD. (JP) | 2000-11-21 | — | — | US | disclosed |
| EP-0950656-A1 | SULFONATED AMINO ACID DERIVATIVES AND METALLOPROTEINASE INHIBITORS CONTAINING THE SAME | SHIONOGI & CO., LTD. (JP) | 1999-10-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139379-A1 | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same | MMP9, MMP2, MMP1 | HTR6 2090/4885HTR3A 1857/4885LMNA 1941/4885 |
| US-20030225043-A1 | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same | MMP9, MMP2, MMP1 | HTR6 2090/4885HTR3A 1857/4885LMNA 1941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.