Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | LPAR2 | Q9HBW0 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14305177 | 0.80 | HDAC8 (0.70) | MEN1KMT2APOLBHPGDALDH1A1 | |
| SCHEMBL11884278 | 0.79 | ALDH1A1 (0.67) | MEN1KMT2APOLBCASP1HPGD | |
| SCHEMBL7604289 | 0.77 | SLC6A2 (0.55) | MEN1KMT2AHPGDALDH1A1HSD17B10 | |
| SCHEMBL8689214 | 0.77 | ALDH1A1 (0.79) | MEN1KMT2APOLBHPGDALDH1A1 | |
| SCHEMBL1665592 | 0.76 | ALDH1A1 (0.67) | KMT2APOLBHPGDALDH1A1HSD17B10 | |
| SCHEMBL9135860 | 0.74 | MAPT (0.68) | MEN1KMT2APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL993102 | 0.74 | HPGD (0.65) | POLBHPGDALDH1A1HSD17B10HTT | |
| SCHEMBL5515007 | 0.74 | ALDH1A1 (0.81) | POLBHPGDALDH1A1HSD17B10MAPT | |
| SCHEMBL22182078 | 0.74 | LPAR2 (0.51) | MEN1KMT2APOLBCASP1HPGD | |
| SCHEMBL9218494 | 0.73 | ACHE (0.66) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028912-A1 | Methods of modulating bromodomains | J.David Gladstone Institute | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028912-A1 | Methods of modulating bromodomains | BAZ2A, BRPF3, BRD3 | MEN1 4767/4885KMT2A 255/4885POLB 1307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.