Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.52 |
| ▸ | HPGD | P15428 | 7/20 | 0.52 |
| ▸ | GLA | P06280 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | NQO1 | P15559 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5429225 | 0.87 | KDM4E (0.67) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL869935 | 0.82 | KDM4E (0.67) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL12221067 | 0.82 | CYP3A4 (0.53) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL12920147 | 0.79 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL12919918 | 0.78 | MCL1 (0.61) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL31344274 | 0.78 | MCL1 (0.47) | KDM4EALDH1A1HPGDGLALCK | |
| SCHEMBL67273 | 0.78 | MCL1 (0.47) | KDM4EALDH1A1HPGDGLALCK | |
| SCHEMBL14473923 | 0.75 | KDM4E (0.49) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL24025683 | 0.75 | MCL1 (0.47) | KDM4EALDH1A1HPGDGLALCK | |
| SCHEMBL12993677 | 0.75 | KDM4E (0.49) | KDM4EALDH1A1HPGDGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160128321-A1 | Ladder-Frame Polyether Conjugates | UNIVERSITY OF NORTH CAROLINA AT WILMINGTON | 2016-05-12 | — | — | US | disclosed |
| US-20140073604-A1 | Ladder-Frame Polyether Conjugates | UNIVERSITY OF NORTH CAROLINA AT WILMINGTON (US) | 2014-03-13 | — | — | US | disclosed |
| US-20120077778-A1 | Ladder-Frame Polyether Conjugates | UNIVERSITY OF NORTH CAROLINA AT WILMINGTON | 2012-03-29 | — | — | US | disclosed |
| US-20120077778-A1 | Ladder-Frame Polyether Conjugates | UNIVERSITY OF NORTH CAROLINA AT WILMINGTON | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140073604-A1 | Ladder-Frame Polyether Conjugates | ABCB4, NUP210, BCR | KDM4E 4331/4885ALDH1A1 2158/4885HPGD 2918/4885 |
| US-20120077778-A1 | Ladder-Frame Polyether Conjugates | ABCB4, NUP210, BCR | KDM4E 4331/4885ALDH1A1 2158/4885HPGD 2918/4885 |
| US-20160128321-A1 | Ladder-Frame Polyether Conjugates | ABCB4, NUP210, BCR | KDM4E 4331/4885ALDH1A1 2158/4885HPGD 2918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.