Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.61 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL11252247 | 1.00 | CA5A (0.61) | CA5ACA5BALDH1A1HPGDHIF1A | |
| Guanidine SCHEMBL27574673 | 1.00 | CA5A (0.61) | CA5ACA5BALDH1A1HPGDHIF1A | |
| Guanidine SCHEMBL21392 | 1.00 | — | — | |
| Guanidine SCHEMBL742686 | 1.00 | CA5A (0.61) | CA5ACA5BALDH1A1HPGDHIF1A | |
| Guanidine SCHEMBL17844261 | 1.00 | CA5A (0.61) | CA5ACA5BALDH1A1HPGDHIF1A | |
| Guanidine SCHEMBL6384671 | 1.00 | CA5A (0.61) | CA5ACA5BALDH1A1HPGDHIF1A | |
| Guanidine SCHEMBL8852023 | 1.00 | CA5A (0.61) | CA5ACA5BALDH1A1HPGDHIF1A | |
| Guanidine SCHEMBL4613000 | 0.96 | — | — | |
| Guanidine SCHEMBL28603290 | 0.96 | CA5A (0.57) | CA5ACA5BALDH1A1HPGDHIF1A | |
| Guanidine SCHEMBL27704650 | 0.96 | CA5A (0.57) | CA5ACA5BALDH1A1HPGDHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271601-B1 | GAS GENERATION FOR A SAFETY DEVICE, THE CHARGE OF WHICH IS INITIATED BY A HEAT-GENERATING MEANS | AUTOLIV DEV (SE) | 2017-05-03 | — | — | EP | claimed |
| EP-2271601-A1 | GAS GENERATION FOR A SEFETY DEVICE, THE CHARGE OF WHICH IS INITIATED BY A HEAT-GENERATING MEANS | Autoliv Development AB (SE) | 2011-01-12 | — | — | EP | claimed |
| US-20100320735-A1 | GAS GENERATION FOR A SAFETY DEVICE, THE CHARGE OF WHICH IS INITIATED BY A HEAT-GENERATING MEANS | AUTOLIV DEVELOPMENT AB (SE) | 2010-12-23 | — | — | US | claimed |
| WO-2009098085-A1 | GAS GENERATION FOR A SEFETY DEVICE, THE CHARGE OF WHICH IS INITIATED BY A HEAT-GENERATING MEANS | AUTOLIV DEVELOPMENT AB (SE) | 2009-08-13 | — | — | WO | claimed |
| EP-0716058-B1 | Gas generating mixture | FRAUNHOFER GES FORSCHUNG (DE) | 1997-08-13 | — | — | EP | claimed |
| US-5034073-A | Explosive composition with binder | AEROJET GENERAL CORPORATION (US) | 1991-07-23 | — | — | US | claimed |
| CN-115959957-A | Method for preparing gas generating agent composition by using waste basic copper nitrate and application | 南京理工大学 | 2023-04-14 | — | — | CN | disclosed |
| CN-115894138-A | Method for recycling waste copper nitrate containing guanidine alkali and application | 南京理工大学 | 2023-04-04 | — | — | CN | disclosed |
| US-11608025-B2 | Protection system for persons and goods comprising an inflatable structure with long duration of action | CORD PAUL PHILIPPE (FR) | 2023-03-21 | — | — | US | disclosed |
| CN-110730736-B | Protection system for persons and objects comprising an inflatable structure with a long duration action | 保罗·菲利普·科德 | 2022-12-13 | — | — | CN | disclosed |
| CN-107394115-B | Negative electrode for lithium metal battery and lithium metal battery including the same | 三星电子株式会社 | 2022-03-29 | — | — | CN | disclosed |
| CN-107359309-B | Negative electrode for lithium metal battery and lithium metal battery including the same | 三星电子株式会社 | 2022-01-18 | — | — | CN | disclosed |
| US-20200331424-A1 | PROTECTION SYSTEM FOR PERSONS AND GOODS COMPRISING AN INFLATABLE STRUCTURE WITH LONG DURATION OF ACTION | CORD PAUL PHILIPPE (FR) | 2020-10-22 | — | — | US | disclosed |
| US-5739460-A | Method of safely initiating combustion of a gas generant composition using an autoignition composition | TALLEY DEFENSE SYSTEMS, INC. (US) | 1998-04-14 | — | — | US | disclosed |
| WO-1997045294-A2 | AUTOIGNITION COMPOSITION | TALLEY DEFENSE SYSTEMS, INC. (US) | 1997-12-04 | — | — | WO | disclosed |
| US-4707478-A | ANTIPROTOZOA AGENTS | RORER PHARMACEUTICAL CORPORATION (US) | 1987-11-17 | — | — | US | disclosed |
| US-4535185-A | USING A SI02 OR SILICA GEL CATALYST | INDUSTRIE CHEMIE THOMA GMBH & CO PRODUKTIONS KG (DE) | 1985-08-13 | — | — | US | disclosed |
| EP-0086775-A4 | HETEROCYCLIC AMIDINO SUBSTITUTED UREAS AND THEIR PHARMACEUTICAL USES. | RORER INTERNAT OVERSEAS INC (US) | 1984-09-05 | — | — | EP | disclosed |
| EP-0086775-A1 | HETEROCYCLIC AMIDINO SUBSTITUTED UREAS AND THEIR PHARMACEUTICAL USES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1983-08-31 | — | — | EP | disclosed |
| WO-1983000627-A1 | HETEROCYCLIC AMIDINO SUBSTITUTED UREAS AND THEIR PHARMACEUTICAL USES | STUDT, WILLIAM, LYON | 1983-03-03 | — | — | WO | disclosed |