Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.61 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL11252247 | 1.00 | CA5A (0.61) | CA5ACA5BALDH1A1HPGDHIF1A | |
| Guanidine SCHEMBL1013287 | 1.00 | CA5A (0.61) | CA5ACA5BALDH1A1HPGDHIF1A | |
| Guanidine SCHEMBL27574673 | 1.00 | CA5A (0.61) | CA5ACA5BALDH1A1HPGDHIF1A | |
| Guanidine SCHEMBL21392 | 1.00 | — | — | |
| Guanidine SCHEMBL742686 | 1.00 | CA5A (0.61) | CA5ACA5BALDH1A1HPGDHIF1A | |
| Guanidine SCHEMBL17844261 | 1.00 | CA5A (0.61) | CA5ACA5BALDH1A1HPGDHIF1A | |
| Guanidine SCHEMBL6384671 | 1.00 | CA5A (0.61) | CA5ACA5BALDH1A1HPGDHIF1A | |
| Guanidine SCHEMBL4613000 | 0.96 | — | — | |
| Guanidine SCHEMBL28603290 | 0.96 | CA5A (0.57) | CA5ACA5BALDH1A1HPGDHIF1A | |
| Guanidine SCHEMBL27704650 | 0.96 | CA5A (0.57) | CA5ACA5BALDH1A1HPGDHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670615-A | ACIDIFICATION OF QUATERNIZED AMINOMETHYLATED ACRYLAMIDE, ADDING A FORMALDEHYDE SCAVENGER AND WATER, HEATING A MICROEMULSION | CYTEC TECHNOLOGY CORP. (US) | 1997-09-23 | — | — | US | disclosed |