Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.54 |
| ▸ | TUBB | P07437 | 5/20 | 0.54 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.54 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.54 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.54 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.54 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.54 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.54 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.54 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.54 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.54 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.54 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.54 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.54 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10133026 | 0.89 | TUBB4A (0.57) | LTA4HNPC1RAB9ATUBB4ATUBB | |
| SCHEMBL10132819 | 0.88 | SRC (0.68) | LTA4HNPC1RAB9ATUBB4ATUBB | |
| SCHEMBL10132964 | 0.86 | TUBB4A (0.63) | LTA4HNPC1RAB9ATUBB4ATUBB | |
| SCHEMBL10132968 | 0.85 | AURKA (0.61) | LTA4HNPC1RAB9ATUBB4ATUBB | |
| SCHEMBL10132927 | 0.83 | ABL1 (0.62) | LTA4HNPC1RAB9ATUBB4ATUBB | |
| SCHEMBL10133030 | 0.82 | TUBB4A (0.58) | LTA4HNPC1RAB9ATUBB4ATUBB | |
| SCHEMBL11917546 | 0.81 | TUBB4A (0.81) | LTA4HNPC1RAB9ATUBB4ATUBB | |
| SCHEMBL10132967 | 0.80 | LTA4H (0.64) | LTA4HNPC1RAB9A | |
| SCHEMBL10132825 | 0.78 | TUBB4A (0.71) | LTA4HNPC1RAB9ATUBB4ATUBB | |
| SCHEMBL10133046 | 0.78 | MGLL (0.65) | NPC1RAB9AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124605-B2 | Compositions and methods for modulating a kinase cascade | KINEX PHARMACEUTICALS, LLC (US) | 2012-02-28 | — | — | US | disclosed |
| US-8124605-B2 | Compositions and methods for modulating a kinase cascade | KINEX PHARMACEUTICALS, LLC (US) | 2012-02-28 | — | — | US | disclosed |
| US-20090149510-A1 | Compositions and methods for modulating a kinase cascade | OAKTREE FUND ADMINISTRATION, LLC | 2009-06-11 | — | — | US | disclosed |
| US-20090149510-A1 | Compositions and methods for modulating a kinase cascade | OAKTREE FUND ADMINISTRATION, LLC | 2009-06-11 | — | — | US | disclosed |
| WO-2009009041-A2 | COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | KINEX PHARMACEUTICALS, LLC (US) | 2009-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149510-A1 | Compositions and methods for modulating a kinase cascade | MAP3K6, MAP3K4, MAP3K3 | LTA4H 3326/4885NPC1 3447/4885RAB9A 2804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.