Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 11/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | PLAT | P00750 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28226196 | 0.91 | HTR6 (0.54) | HTR6HSD11B1 | |
| SCHEMBL1015179 | 0.88 | HTR6 (0.55) | HTR6 | |
| SCHEMBL1013032 | 0.88 | HTR6 (0.55) | HTR6 | |
| SCHEMBL1015422 | 0.84 | HTR6 (0.52) | HTR6 | |
| SCHEMBL20380052 | 0.81 | HTR6 (0.41) | HTR6 | |
| SCHEMBL9732296 | 0.81 | HTR6 (0.42) | HTR6 | |
| SCHEMBL14142576 | 0.79 | HTR6 (0.56) | HTR6HSD11B1 | |
| SCHEMBL1014428 | 0.79 | HTR6 (0.52) | HTR6PLAT | |
| SCHEMBL10180872 | 0.79 | HSD11B1 (0.54) | HTR6HSD11B1 | |
| SCHEMBL1069517 | 0.79 | HTR6 (0.55) | HTR6PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081890-B1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-01-12 | — | — | EP | disclosed |
| US-7776910-B2 | Arylsulfonyl pyrrolidines as 5-HT6 inhibitors | ROCHE PALO ALTO LLC (US) | 2010-08-17 | — | — | US | disclosed |
| US-20080167361-A1 | Arylsulfonyl pyrrolidines as 5-HT6 inhibitors | ROCHE PALO ALTO LLC | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167361-A1 | Arylsulfonyl pyrrolidines as 5-HT6 inhibitors | HTR6, HTR1B, HTR1F | HTR6 1/4885HSD11B1 2871/4885PLAT 4627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.