Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 8/20 | 0.58 |
| ▸ | NPC1 | O15118 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25786633 | 0.88 | RAB9A (0.57) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2D6 | |
| SCHEMBL1739337 | 0.84 | ALDH1A1 (0.61) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2D6 | |
| SCHEMBL864467 | 0.83 | KMT2A (0.59) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2D6 | |
| SCHEMBL26910772 | 0.83 | NPC1 (0.56) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2D6 | |
| SCHEMBL20156306 | 0.81 | RAB9A (0.55) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2D6 | |
| SCHEMBL23705472 | 0.80 | KMT2A (0.53) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2D6 | |
| SCHEMBL795573 | 0.80 | NPC1 (0.53) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2D6 | |
| SCHEMBL28851114 | 0.80 | NPC1 (0.53) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2D6 | |
| SCHEMBL23773671 | 0.80 | RAB9A (0.53) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2D6 | |
| SCHEMBL10026496 | 0.80 | KMT2A (0.64) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035237-A1 | PYRAZOLE AND TRIAZOLE CARBOXAMIDES AS CRAC CHANN EL INHIBITORS | COE DIANE MARY (GB) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035237-A1 | PYRAZOLE AND TRIAZOLE CARBOXAMIDES AS CRAC CHANN EL INHIBITORS | RYR2, PAICS, CTRC | ALDH1A1 1856/4885KMT2A 3378/4885CYP1A2 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.