Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 12/20 | 0.37 |
| ▸ | JAK1 | P23458 | 12/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10134343 | 0.89 | MAPKAPK5 (0.50) | MAPKAPK5AURKAJAK2JAK1AURKB | |
| SCHEMBL10133631 | 0.83 | MAPKAPK5 (0.48) | MAPKAPK5CCNA2CDK2CYP1A2CYP3A4 | |
| SCHEMBL1685156 | 0.83 | MAPKAPK5 (0.51) | MAPKAPK5AURKAJAK2CCNA2CDK2 | |
| SCHEMBL10133592 | 0.83 | MAPKAPK5 (0.49) | MAPKAPK5AURKAJAK2JAK1CDK2 | |
| SCHEMBL14162836 | 0.82 | MAPKAPK5 (0.50) | MAPKAPK5AURKAJAK2ROCK2 | |
| SCHEMBL14162793 | 0.81 | MAPKAPK5 (0.50) | MAPKAPK5ROCK2 | |
| SCHEMBL14162745 | 0.81 | MAPKAPK5 (0.58) | MAPKAPK5AURKAJAK2JAK1CDK2 | |
| SCHEMBL12618824 | 0.81 | MAPKAPK5 (0.44) | MAPKAPK5JAK2JAK1 | |
| SCHEMBL13922261 | 0.80 | MAPKAPK5 (0.49) | MAPKAPK5JAK2JAK1CCNA2CDK2 | |
| SCHEMBL14162528 | 0.79 | MAPKAPK5 (0.48) | MAPKAPK5ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010206-A1 | IMIDAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS N. V. (BE) | 2012-01-12 | — | — | US | disclosed |
| US-7951818-B2 | Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases | GALAPAGOS NV (BE) | 2011-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010206-A1 | IMIDAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | COL2A1, MMP1, COL1A1 | MAPKAPK5 19/4885AURKA 3833/4885JAK2 1510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.