Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.49 |
| ▸ | TYK2 | P29597 | 3/20 | 0.40 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.34 |
| ▸ | EIF4E | P06730 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | F9 | P00740 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CLK3 | P49761 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14162483 | 0.92 | MAPKAPK5 (0.58) | MAPKAPK5TYK2GSK3BPIM1PIK3CD | |
| SCHEMBL10133644 | 0.90 | MAPKAPK5 (0.49) | MAPKAPK5TYK2TP53BP1GSK3BMKNK1 | |
| SCHEMBL10133647 | 0.90 | MAPKAPK5 (0.51) | MAPKAPK5TYK2TP53BP1GSK3BPIK3CD | |
| SCHEMBL10133621 | 0.86 | MAPKAPK5 (0.55) | MAPKAPK5GSK3BMKNK1F9PIK3CD | |
| SCHEMBL10133598 | 0.85 | MAPKAPK5 (0.47) | MAPKAPK5TYK2PIM1CLK2CLK3 | |
| SCHEMBL10133626 | 0.84 | MAPKAPK5 (0.54) | MAPKAPK5TP53BP1GSK3BMKNK1MKNK2 | |
| SCHEMBL10133624 | 0.83 | MAPKAPK5 (0.66) | MAPKAPK5GSK3BMKNK1MKNK2PIK3CD | |
| SCHEMBL1685144 | 0.83 | MAPKAPK5 (0.47) | MAPKAPK5TYK2TP53BP1GSK3BMKNK1 | |
| SCHEMBL14162498 | 0.82 | MAPKAPK5 (0.57) | MAPKAPK5TYK2GSK3BPIK3CDPIK3CA | |
| SCHEMBL1685207 | 0.82 | MAPKAPK5 (0.60) | MAPKAPK5TYK2MKNK1MKNK2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010206-A1 | IMIDAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS N. V. (BE) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010206-A1 | IMIDAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | COL2A1, MMP1, COL1A1 | MAPKAPK5 19/4885TYK2 67/4885TP53BP1 446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.