Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 5/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | RECQL | P46063 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | STS | P08842 | 8/20 | 0.70 |
| ▸ | ESR1 | P03372 | 2/20 | 0.69 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.69 |
| ▸ | CA1 | P00915 | 2/20 | 0.69 |
| ▸ | CA2 | P00918 | 2/20 | 0.69 |
| ▸ | CA9 | Q16790 | 2/20 | 0.69 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.69 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.69 |
| ▸ | CA4 | P22748 | 1/20 | 0.69 |
| ▸ | CA6 | P23280 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6691697 | 1.00 | HSD17B1 (0.74) | HSD17B1KDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL11672003 | 0.96 | HSD17B1 (0.74) | HSD17B1KDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL14044784 | 0.96 | HSD17B1 (0.74) | HSD17B1KDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL9633204 | 0.92 | KDM4E (0.75) | HSD17B1KDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL14377634 | 0.92 | KDM4E (0.72) | HSD17B1KDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL3322353 | 0.92 | KDM4E (0.67) | HSD17B1KDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL7755033 | 0.92 | HSD17B1 (0.74) | HSD17B1KDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL11671118 | 0.91 | HSD17B1 (0.78) | HSD17B1KDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL5527434 | 0.91 | HSD17B1 (0.78) | HSD17B1KDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL6694124 | 0.91 | KDM4E (0.71) | HSD17B1KDM4ELMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124614-B2 | Steroidal compounds for inhibiting steroid sulphatase | STERIX LIMITED (GB) | 2012-02-28 | — | — | US | disclosed |
| US-8003783-B2 | Steroid 17 beta -hydroxysteroid dehydrogenase inhibitors substituted with one or more oxime groups, especially aromatase inhibitors used in the treatment of endocrine-dependent tumors, especially breast cancer | STERIX LIMITED (GB) | 2011-08-23 | — | — | US | disclosed |
| EP-2336146-A1 | 17beta-hydroxysteroid dehydrogenase inhibitors | Sterix Limited (GB) | 2011-06-22 | — | — | EP | disclosed |
| US-20080312266-A1 | Steroidal Compounds For Inhibiting Steroid Sulphatase | RICHTER GEDEON NYRT. (HU) | 2008-12-18 | — | — | US | disclosed |
| US-7276513-B2 | Steroidal compounds for inhibiting steroid sulphatase | STERIX, LTD. (GB) | 2007-10-02 | — | — | US | disclosed |
| US-20070105886-A1 | Steroidal compounds for inhibiting steroid sulphatase | RICHTER GEDEON NYRT. (HU) | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312266-A1 | Steroidal Compounds For Inhibiting Steroid Sulphatase | STS, NR5A1, CYP21A2 | HSD17B1 11/4885KDM4E 2571/4885LMNA 4488/4885 |
| US-20070105886-A1 | Steroidal compounds for inhibiting steroid sulphatase | STS, NR5A1, CYP21A2 | HSD17B1 11/4885KDM4E 2571/4885LMNA 4488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.