SCHEMBL1013413

SCHEMBL1013413

COc1cc(C)nc(NC(=O)NS(=O)(=O)Nc2ccccc2C(C)=O)n1

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
ALOX15 P16050 1/20 0.47
GAA P10253 2/20 0.45
THRB P10828 1/20 0.43
MAPT P10636 3/20 0.41
TP53 P04637 1/20 0.41
GLA P06280 1/20 0.41
HTT P42858 2/20 0.40
CYP1A2 P05177 1/20 0.40
ALDH1A1 P00352 2/20 0.40
LMNA P02545 1/20 0.40
HIF1A Q16665 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
KDM4E B2RXH2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8380205 0.94 GAA (0.51) TSHRSMN1; SMN2ALOX15GAAMAPT
SCHEMBL9248108 0.89 TSHR (0.48) TSHRSMN1; SMN2ALOX15GAATHRB
SCHEMBL7809237 0.89 CDK1 (0.49) TSHRSMN1; SMN2ALOX15GAATHRB
SCHEMBL10946516 0.88 TSHR (0.51) TSHRSMN1; SMN2ALOX15GAAMAPT
SCHEMBL10946515 0.87 TSHR (0.50) TSHRSMN1; SMN2ALOX15GAATHRB
SCHEMBL10944770 0.85 TSHR (0.51) TSHRSMN1; SMN2ALOX15GAAMAPT
SCHEMBL8535695 0.85 GAA (0.51) TSHRGAAMAPTTP53GLA
SCHEMBL7808085 0.84 GAA (0.50) SMN1; SMN2ALOX15GAAMAPTTP53
SCHEMBL1014139 0.83 ALOX15 (0.40) SMN1; SMN2ALOX15THRBHTTALDH1A1
SCHEMBL8794044 0.83 GAA (0.52) TSHRSMN1; SMN2GAATHRBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5407897-A Plant safening agents AMERICAN CYANAMID COMPANY (US) 1995-04-18 US claimed
EP-0965265-B1 AHAS-inhibiting herbicide resistant wheat and method for selection thereof BASF SE (DE) 2011-01-05 EP disclosed
US-7034208-B1 Ahas inhibiting herbicide resistant wheat and method for selection thereof BASF AKTIENGELLSCHAFT (DE) 2006-04-25 US disclosed
US-6339184-B1 SCREENING FOR THE SELECTION OF MUTATIONS WHICH CONFER ACETOHYDROXYACID SYNTHASE RESISTANCE TO WHEAT BASF AKTIENGELLSCHAFT (DE) 2002-01-15 US disclosed
EP-0508161-B1 Use of AHAS inhibiting herbicide resistant wheat and method for selection thereof AMERICAN CYANAMID CO (US) 2000-05-10 EP disclosed
EP-0965265-A2 AHAS-inhibiting herbicide resistant wheat and method for selection thereof AMERICAN CYANAMID COMPANY (US) 1999-12-22 EP disclosed
EP-0716073-B1 Process for safening herbicides in cereal crops using 5-aryloxy-1,2-(disubstituted) benzene compounds AMERICAN CYANAMID CO (US) 1999-03-31 EP disclosed
US-5696050-A APPLYING TO CROP PLANT, SEED OR SURROUNDING SOIL OR WATER ANTIDOTAL AMOUNT OF PLANT SAFENING AGENT AMERICAN CYANAMID COMPANY (US) 1997-12-09 US disclosed
EP-0613618-B1 Method for safening herbicides in crops using substituted benzopyran and tetrahydronaphthalene compounds AMERICAN CYANAMID CO (US) 1997-04-16 EP disclosed
US-5596124-A FOR USE WITH CEREAL CROPS AMERICAN CYANAMID COMPANY (US) 1997-01-21 US disclosed
EP-0716073-A1 Process for safening herbicides in cereal crops using 5-aryloxy-1,2-(disubstituted) benzene compounds American Cyanamid Company (US) 1996-06-12 EP disclosed
US-5516918-A PLANT SAFTENING AGENTS USING BENZOPYRAN-4-ACETIC ACIDS OR BENZOTHIOPYRAN-4-ACETIC ACIDS AMERICAN CYANAMID COMPANY (US) 1996-05-14 US disclosed
US-5407897-A Plant safening agents AMERICAN CYANAMID COMPANY (US) 1995-04-18 US disclosed
EP-0613618-A1 Method for safening herbicides in crops using substituted benzopyran and tetrahydronaphthalene compounds AMERICAN CYANAMID COMPANY (US) 1994-09-07 EP disclosed
EP-0508161-A1 AHAS inhibiting herbicide resistant wheat and method for selection thereof AMERICAN CYANAMID COMPANY (US) 1992-10-14 EP disclosed