Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 18/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10105792 | 0.90 | GPR119 (0.53) | GPR119LRRK2SRC | |
| SCHEMBL10120673 | 0.88 | GPR119 (0.50) | GPR119 | |
| SCHEMBL10120558 | 0.86 | GPR119 (0.51) | GPR119LRRK2SRC | |
| SCHEMBL10120568 | 0.86 | GPR119 (0.54) | GPR119LRRK2SRC | |
| SCHEMBL10120490 | 0.82 | GPR119 (0.47) | GPR119LRRK2SRC | |
| SCHEMBL10134273 | 0.81 | AR (0.42) | GPR119 | |
| SCHEMBL10120508 | 0.81 | GPR119 (0.51) | GPR119LRRK2SRC | |
| SCHEMBL10134274 | 0.79 | GPR119 (0.53) | GPR119 | |
| SCHEMBL10120672 | 0.79 | GPR119 (0.47) | GPR119 | |
| SCHEMBL12319936 | 0.77 | GPR119 (0.58) | GPR119LRRK2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021976-A1 | BICYCLIC PIPERIDINE AND PIPERAZINE DERIVATIVES AS GPCR MODULATORS FOR THE TREATMENT OF OBESITY, DIABETES AND OTHER METABOLIC DISORDERS | MERCK SHARP & DOHME LLC | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120021976-A1 | BICYCLIC PIPERIDINE AND PIPERAZINE DERIVATIVES AS GPCR MODULATORS FOR THE TREATMENT OF OBESITY, DIABETES AND OTHER METABOLIC DISORDERS | GPR119, GPR55, GPR4 | GPR119 1/4885LRRK2 463/4885SRC 2958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.