Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | IKBKB | O14920 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.43 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.43 |
| ▸ | TRIB2 | Q92519 | 1/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | CHUK | O15111 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10135728 | 1.00 | CYP19A1 (0.45) | CYP19A1IKBKBHRH3SLC6A2CHRM2 | |
| SCHEMBL10135742 | 1.00 | CYP19A1 (0.45) | CYP19A1IKBKBHRH3SLC6A2CHRM2 | |
| SCHEMBL10135790 | 0.93 | HRH3 (0.44) | CYP19A1IKBKBHRH3SLC6A2CHRM2 | |
| SCHEMBL10135774 | 0.93 | HRH3 (0.44) | CYP19A1IKBKBHRH3SLC6A2CHRM2 | |
| SCHEMBL10135762 | 0.93 | HRH3 (0.46) | CYP19A1IKBKBHRH3SLC6A2CHRM2 | |
| SCHEMBL10135797 | 0.89 | CYP19A1 (0.44) | CYP19A1IKBKBHRH3SLC6A2CHRM2 | |
| SCHEMBL10135627 | 0.89 | CYP19A1 (0.46) | CYP19A1IKBKBHRH3SLC6A2CHRM2 | |
| SCHEMBL10135624 | 0.82 | ROCK1 (0.46) | CYP19A1HRH3SLC6A2CHRM2PIM1 | |
| SCHEMBL10135637 | 0.82 | ROCK1 (0.46) | CYP19A1HRH3SLC6A2CHRM2PIM1 | |
| SCHEMBL10135719 | 0.81 | ROCK2 (0.45) | CYP19A1IKBKBACHEPRKCZCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8951997-B2 | Substituted isoquinoline derivative | D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) | 2015-02-10 | — | — | US | disclosed |
| US-20120035159-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. WESTERN THERAPEUTICS INSTITUTE, INC (JP) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035159-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | SULT1A1, SULT1E1, SULT2A1 | CYP19A1 2996/4885IKBKB 645/4885HRH3 563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.