Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.56 |
| ▸ | CA2 | P00918 | 3/20 | 0.56 |
| ▸ | CA9 | Q16790 | 3/20 | 0.56 |
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA4 | P22748 | 1/20 | 0.56 |
| ▸ | CA5A | P35218 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.56 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.48 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32664684 | 0.87 | ABCB1 (0.50) | CA1CA2CA9CA12CA4 | |
| SCHEMBL10619752 | 0.87 | ABCB1 (0.50) | CA1CA2CA9CA12CA4 | |
| SCHEMBL7108877 | 0.85 | MAPT (0.53) | CA1CA2CA9CA12CA4 | |
| SCHEMBL29965415 | 0.84 | NPC1 (0.54) | CA1CA2CA9CA12CA4 | |
| SCHEMBL10622816 | 0.83 | HTR1A (0.55) | CA1CA2CA9CA12MAPK1 | |
| SCHEMBL32664452 | 0.83 | HTR1A (0.55) | CA1CA2CA9CA12MAPK1 | |
| SCHEMBL1028419 | 0.82 | ALPG (0.51) | MAPTMAPK1TDP1L3MBTL1LTA4H | |
| SCHEMBL1500952 | 0.82 | MAPT (0.50) | CA1CA2CA9CA12CA4 | |
| SCHEMBL4164605 | 0.82 | MAPT (0.55) | MAPTMAPK1TDP1L3MBTL1LTA4H | |
| SCHEMBL4649389 | 0.81 | CA1 (0.48) | CA1CA2CA9CA12CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0044807-B1 | N-PHENYLSULFONYL-N'-PYRIMIDINYL- AND -TRIAZINYL UREAS | CIBA-GEIGY AG (CH) | 1985-11-21 | — | — | EP | claimed |
| EP-3122353-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | Vanderbilt University (US) | 2017-02-01 | — | — | EP | disclosed |
| WO-2015148854-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY (US) | 2015-10-01 | — | — | WO | disclosed |
| US-8048862-B2 | Macrocyclic inhibitors of hepatitis C virus replication | INTERMUNE, INC. (US) | 2011-11-01 | — | — | US | disclosed |
| US-20110059047-A1 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2011-03-10 | — | — | US | disclosed |
| EP-2272858-A2 | HCV inhibitors comprising beta amino acids and their uses | Novartis AG (CH) | 2011-01-12 | — | — | EP | disclosed |
| US-20090269305-A1 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-10-29 | — | — | US | disclosed |
| US-4661146-A | PLANT GROWTH REGULATORS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-04-28 | — | — | US | disclosed |
| US-4565887-A | PLANT GROWTH AGENTS, HERBICIDES | CIBA-GEIGY CORP. (US) | 1986-01-21 | — | — | US | disclosed |
| US-4523944-A | HERBICIDES | CIBA-GEIGY CORPORATION (US) | 1985-06-18 | — | — | US | disclosed |
| US-4500344-A | Herbicidal ortho-(alkoxy)-benzenesulfonamides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-02-19 | — | — | US | disclosed |
| US-4487951-A | INTERMEDIATES FOR PLANT GROWTH REGULATORS AND HERBICIDES | CIBA-GEIGY CORPORATION (US) | 1984-12-11 | — | — | US | disclosed |
| US-4443243-A | HERBICIDES | CIBA-GEIGY CORPORATION (US) | 1984-04-17 | — | — | US | disclosed |
| US-4425153-A | Herbicidal sulfonamides | E. I. DU PONT DE NEMOURS & CO. (US) | 1984-01-10 | — | — | US | disclosed |
| EP-0094790-A2 | Herbicidal O-alkoxybenzenesulfonamides | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-11-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090269305-A1 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | EIF2AK2, HAVCR2, ZC3HAV1 | CA1 4730/4885CA2 4581/4885CA9 4082/4885 |
| US-20110059047-A1 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | EIF2AK2, HAVCR2, ZC3HAV1 | CA1 4730/4885CA2 4581/4885CA9 4082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.