SCHEMBL10136637

SCHEMBL10136637

CNC(=O)c1cc(C#N)cc(C)c1NC(=O)c1cc(Nc2cc(C(F)(F)F)ccn2)nn1-c1ncccc1Cl

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
EPAS1 Q99814 1/20 0.36
LMNA P02545 1/20 0.36
POLB P06746 1/20 0.36
ELANE P08246 2/20 0.35
SYK P43405 7/20 0.35
SLC2A1 P11166 3/20 0.35
SLC2A3 P11169 3/20 0.35
SLC2A4 P14672 3/20 0.35
SLC2A2 P11168 1/20 0.35
DHODH Q02127 1/20 0.34
JAK1 P23458 1/20 0.33
TYK2 P29597 1/20 0.33
STAT3 P40763 1/20 0.33
KCNH2 Q12809 1/20 0.33
MAP3K12 Q12852 1/20 0.33
CNR1 P21554 1/20 0.33
CNR2 P34972 1/20 0.33
TRPV1 Q8NER1 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10136251 0.91 KCNH2 (0.40) LMNAPOLBSLC2A1SLC2A3SLC2A4
SCHEMBL10136916 0.90 MAPK9 (0.35) SLC2A1SLC2A3SLC2A4SLC2A2JAK1
SCHEMBL10136318 0.89 SLC2A1 (0.35) ELANESYKSLC2A1SLC2A3SLC2A4
SCHEMBL782240 0.86 SLC2A1 (0.38) ELANESLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL10118401 0.84 TRPV1 (0.37) SLC2A1SLC2A3SLC2A4SLC2A2DHODH
SCHEMBL10136940 0.84 MEN1 (0.38) LMNAPOLBSYK
SCHEMBL10118409 0.84 KCNH2 (0.36) SLC2A1SLC2A3SLC2A4SLC2A2DHODH
SCHEMBL13239852 0.84 KMT2A (0.35) SLC2A1SLC2A3SLC2A4SLC2A2DHODH
SCHEMBL10136321 0.84 TRPV1 (0.37) SLC2A1SLC2A3SLC2A4SLC2A2DHODH
SCHEMBL10136812 0.84 PSEN1 (0.34) SYKSLC2A1SLC2A3SLC2A4SLC2A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8791139-B2 Anthranilic diamide derivatives BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2012-01-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES DDT, QDPR, ANTXR2 EPAS1 3498/4885LMNA 3458/4885POLB 4330/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.