SCHEMBL10136318

SCHEMBL10136318

CNC(=O)c1cc(C#N)cc(C)c1NC(=O)c1cc(Nc2cccc(C(F)(F)F)n2)nn1-c1ncccc1Cl

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 5/20 0.35
SLC2A3 P11169 5/20 0.35
SLC2A4 P14672 5/20 0.35
SLC2A2 P11168 2/20 0.35
CLK4 Q9HAZ1 5/20 0.35
CSNK2A1 P68400 2/20 0.35
HIPK4 Q8NE63 2/20 0.35
MAP4K4 O95819 1/20 0.35
ELANE P08246 1/20 0.34
TGFBR1 P36897 1/20 0.34
JAK1 P23458 1/20 0.33
TYK2 P29597 1/20 0.33
STAT3 P40763 1/20 0.33
KCNH2 Q12809 1/20 0.33
DHODH Q02127 1/20 0.33
ACVR1 Q04771 3/20 0.33
GSK3A P49840 3/20 0.33
GSK3B P49841 3/20 0.33
CDK8 P49336 3/20 0.33
ABL1 P00519 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10136637 0.89 EPAS1 (0.36) SLC2A1SLC2A3SLC2A4SLC2A2ELANE
SCHEMBL782240 0.88 SLC2A1 (0.38) SLC2A1SLC2A3SLC2A4SLC2A2ELANE
SCHEMBL10136916 0.87 MAPK9 (0.35) SLC2A1SLC2A3SLC2A4SLC2A2JAK1
SCHEMBL10136251 0.87 KCNH2 (0.40) SLC2A1SLC2A3SLC2A4SLC2A2CLK4
SCHEMBL13239852 0.83 KMT2A (0.35) SLC2A1SLC2A3SLC2A4SLC2A2JAK1
SCHEMBL12956899 0.82 PKM (0.42) SLC2A1SLC2A3SLC2A4SLC2A2JAK1
SCHEMBL563502 0.82 KMT2A (0.36) SLC2A1SLC2A3SLC2A4SLC2A2JAK1
SCHEMBL30845280 0.82 KMT2A (0.36) SLC2A1SLC2A3SLC2A4SLC2A2JAK1
SCHEMBL10118299 0.82 SLC2A1 (0.37) SLC2A1SLC2A3SLC2A4SLC2A2ELANE
SCHEMBL12158541 0.82 CARM1 (0.38) SLC2A1SLC2A3SLC2A4SLC2A2ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8791139-B2 Anthranilic diamide derivatives BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2012-01-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES DDT, QDPR, ANTXR2 SLC2A1 3127/4885SLC2A3 3314/4885SLC2A4 3392/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.