Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.39 |
| ▸ | HTR3A | P46098 | 6/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.36 |
| ▸ | HTR3B | O95264 | 4/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31015657 | 0.88 | PDE10A (0.34) | HRH4CYP11B1CYP11B2PIM2ALDH1A1 | |
| SCHEMBL10137342 | 0.86 | KMT2A (0.37) | HRH4CYP11B1CYP11B2PIM2ALDH1A1 | |
| SCHEMBL19867650 | 0.80 | HTR3A (0.53) | HRH4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL10137346 | 0.78 | HRH4 (0.40) | HRH4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL12614839 | 0.72 | ALDH1A1 (0.38) | PIM2ALDH1A1CYP1A2KDM4ECYP3A4 | |
| SCHEMBL28506430 | 0.72 | MAPT (0.40) | HRH4HTR3AALDH1A1KDM4ETSHR | |
| SCHEMBL3803696 | 0.71 | NOS3 (0.38) | HRH4HTR3ACYP11B2KDM4E | |
| SCHEMBL29542633 | 0.71 | HTR3A (0.42) | HRH4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL578540 | 0.71 | HTR3A (0.42) | HRH4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL21236708 | 0.70 | HTR3A (0.44) | HRH4HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120208792-A1 | PROTEIN KINASE MODULATORS | CYLENE PHARMACEUTICALS, INC. (US) | 2012-08-16 | — | — | US | disclosed |
| US-20120208792-A1 | PROTEIN KINASE MODULATORS | CYLENE PHARMACEUTICALS, INC. (US) | 2012-08-16 | — | — | US | disclosed |
| US-8168651-B2 | Protein kinase modulators | CYLENE PHARMACEUTICALS, INC. (US) | 2012-05-01 | — | — | US | disclosed |
| US-8168651-B2 | Protein kinase modulators | CYLENE PHARMACEUTICALS, INC. (US) | 2012-05-01 | — | — | US | disclosed |
| US-20090239859-A1 | PROTEIN KINASE MODULATORS | SENHWA BIOSCIENCES, INC. (TW) | 2009-09-24 | — | — | US | disclosed |
| US-20090239859-A1 | PROTEIN KINASE MODULATORS | SENHWA BIOSCIENCES, INC. (TW) | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208792-A1 | PROTEIN KINASE MODULATORS | PIM1, PIM2, PIM3 | HRH4 4420/4885HTR3A 4233/4885HTR3E 3166/4885 |
| US-20090239859-A1 | PROTEIN KINASE MODULATORS | PIM1, PIM2, PIM3 | HRH4 4420/4885HTR3A 4233/4885HTR3E 3166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.