Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | G6PD | P11413 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1014856 | 0.99 | SERPINE1 (0.51) | SERPINE1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL1015240 | 0.91 | MEN1 (0.46) | SERPINE1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL1014777 | 0.91 | ALDH1A1 (0.46) | SERPINE1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL1013771 | 0.87 | SERPINE1 (0.49) | SERPINE1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL1015397 | 0.86 | SERPINE1 (0.50) | SERPINE1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL1797141 | 0.83 | SERPINE1 (0.55) | SERPINE1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL1798112 | 0.82 | SERPINE1 (0.56) | SERPINE1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL1015522 | 0.79 | RAB9A (0.55) | SERPINE1KDM4EKMT2AALDH1A1NPC1 | |
| SCHEMBL1013772 | 0.77 | KMT2A (0.44) | SERPINE1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL1012592 | 0.77 | SERPINE1 (0.64) | SERPINE1KDM4EALDH1A1NPC1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2990057-B1 | PAI-1 INHIBITOR FOR USE IN ENHANCING THE ANTITUMOR EFFECT OF AN ANTITUMOR AGENT IN A PATIENT | RENASCIENCE CO LTD (JP) | 2019-03-20 | — | — | EP | disclosed |
| EP-2272822-A1 | INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | Renascience CO., LTD. (JP) | 2011-01-12 | — | — | EP | disclosed |