Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.45 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.43 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.43 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.43 |
| ▸ | MCTS1 | Q9ULC4 | 2/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10140278 | 0.92 | SMN1; SMN2 (0.48) | MEN1HTTKMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL8890615 | 0.84 | HTT (0.51) | MEN1HTTKMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL10140271 | 0.80 | CNR1 (0.47) | MEN1HTTKMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL16258930 | 0.79 | RAB9A (0.52) | MEN1KMT2ASMN1; SMN2PTGER4AKR1C3 | |
| SCHEMBL10140900 | 0.79 | MAOB (0.40) | MEN1KMT2ASMN1; SMN2PTGDR2MAPT | |
| SCHEMBL15946997 | 0.78 | PTGER4 (0.66) | MEN1HTTKMT2APTGER4AKR1C3 | |
| SCHEMBL8887875 | 0.77 | MEN1 (0.51) | MEN1HTTKMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL7977426 | 0.77 | CNR1 (0.48) | SMN1; SMN2CNR1CNR2PTGER4FAAH | |
| SCHEMBL10172719 | 0.77 | HDAC1 (0.43) | MEN1HTTKMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL16258974 | 0.76 | RAB9A (0.43) | MEN1HTTKMT2ASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148363-B2 | Heterocyclic compounds as factor IXA inhibitors | SCHERING CORPORATION (US) | 2012-04-03 | — | — | US | disclosed |
| US-20110065682-A1 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | MERCK SHARP & DOHME LLC | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065682-A1 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | F9, F12, F8 | MEN1 994/4885HTT 3243/4885KMT2A 2422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.