Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3417164 | 1.00 | TSHR (0.54) | TSHRSLC1A1LMNAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL28514709 | 0.98 | TSHR (0.52) | TSHRSLC1A1LMNAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL7163088 | 0.98 | TSHR (0.52) | TSHRSLC1A1LMNAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL8615052 | 0.91 | L3MBTL1 (0.50) | TSHRSLC1A1LMNAALDH1A1KDM4E | |
| SCHEMBL131050 | 0.88 | SLC1A1 (0.55) | TSHRSLC1A1LMNAALDH1A1KDM4E | |
| SCHEMBL1318285 | 0.88 | SLC1A1 (0.55) | TSHRSLC1A1LMNAALDH1A1KDM4E | |
| SCHEMBL131049 | 0.88 | SLC1A1 (0.55) | TSHRSLC1A1LMNAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL624146 | 0.86 | SLC1A1 (0.53) | TSHRSLC1A1LMNAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL1238805 | 0.86 | SLC1A1 (0.53) | TSHRSLC1A1LMNAALDH1A1KDM4E | |
| SCHEMBL21180030 | 0.86 | TSHR (0.56) | TSHRSLC1A1LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781554-B1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | THOMAS HELLEDAYS STIFTELSE FOER MEDICINSK FORSKNING (SE) | 2023-06-28 | — | — | EP | disclosed |
| US-20210052587-A1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | MEDICINSK FORSKNING (SE) | 2021-02-25 | — | — | US | disclosed |
| WO-2019201991-A1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING (SE) | 2019-10-24 | — | — | WO | disclosed |
| US-9079834-B2 | HIV protease inhibitors | MERCK CANADA INC. (CA) | 2015-07-14 | — | — | US | disclosed |
| US-9079834-B2 | HIV protease inhibitors | MERCK CANADA INC. (CA) | 2015-07-14 | — | — | US | disclosed |
| US-9079834-B2 | HIV protease inhibitors | MERCK CANADA INC. (CA) | 2015-07-14 | — | — | US | disclosed |
| US-20140018325-A1 | HIV PROTEASE INHIBITORS | MERCK CANADA INC. (CA) | 2014-01-16 | — | — | US | disclosed |
| US-20140018325-A1 | HIV PROTEASE INHIBITORS | MERCK CANADA INC. (CA) | 2014-01-16 | — | — | US | disclosed |
| US-20140018325-A1 | HIV PROTEASE INHIBITORS | MERCK CANADA INC. (CA) | 2014-01-16 | — | — | US | disclosed |
| WO-2012055031-A1 | HIV PROTEASE INHIBITORS | MERCK CANADA INC. (CA) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140018325-A1 | HIV PROTEASE INHIBITORS | PRSS1, SERPINB1, FURIN | TSHR 3430/4885SLC1A1 3723/4885LMNA 2428/4885 |
| US-20210052587-A1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | IL2, THPO, IL6 | TSHR 4655/4885SLC1A1 1152/4885LMNA 4836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.