SCHEMBL1014318

SCHEMBL1014318

O=c1ccncc2cccn12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 1/20 0.44
KDM4E B2RXH2 5/20 0.39
ALDH1A1 P00352 5/20 0.39
HSD17B10 Q99714 3/20 0.39
GLA P06280 1/20 0.39
GAA P10253 1/20 0.39
HPGD P15428 1/20 0.39
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
MAPT P10636 2/20 0.35
CHEK1 O14757 1/20 0.35
LIMK1 P53667 1/20 0.35
MAPK14 Q16539 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
CA12 O43570 2/20 0.34
CA1 P00915 2/20 0.34
CA2 P00918 2/20 0.34
CA9 Q16790 2/20 0.34
CA14 Q9ULX7 2/20 0.34
CYP11B1 P15538 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16376209 0.84 ADORA3 (0.36) ADORA3KDM4EALDH1A1HSD17B10GLA
SCHEMBL3714621 0.78 KDM4E (0.44) ADORA3KDM4EALDH1A1HSD17B10GLA
SCHEMBL9900893 0.73 ADORA3 (0.43) ADORA3KDM4EALDH1A1HSD17B10GLA
SCHEMBL31251989 0.68 KDM4E (0.66) KDM4EALDH1A1HSD17B10GLAGAA
SCHEMBL375596 0.67 ADORA3 (0.47) ADORA3KDM4EALDH1A1HSD17B10GLA
SCHEMBL18237882 0.67 KDM4E (0.41) KDM4EALDH1A1HSD17B10GLAGAA
SCHEMBL27688810 0.67 ALDH1A1 (0.42) KDM4EALDH1A1HSD17B10GLAGAA
SCHEMBL8829284 0.65 ALDH1A1 (0.38) KDM4EALDH1A1HSD17B10GLAGAA
SCHEMBL27835946 0.65 ALDH1A1 (0.41) KDM4EALDH1A1HSD17B10GLAGAA
SCHEMBL16376210 0.65 ADORA3 (0.33) ADORA3KDM4EALDH1A1HPGDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2271648-B1 ISOXAZOLINE LINKED PYRROLO [2,1-C][1,4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND THE PROCESS FOR PREPARATTION THEREOF COUNCIL SCIENT IND RES (IN) 2013-02-13 EP claimed
EP-2271648-A1 ISOXAZOLINE LINKED PYRROLO [2,1-C][1,4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND THE PROCESS FOR PREPARATTION THEREOF Council of Scientific & Industrial Research (IN) 2011-01-12 EP claimed
WO-2009118748-A1 ISOXAZOLINE LINKED PYRROLO[2,1-C[1,4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND THE PROCESS FOR PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2009-10-01 WO claimed
EP-2271648-B1 ISOXAZOLINE LINKED PYRROLO [2,1-C][1,4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND THE PROCESS FOR PREPARATTION THEREOF COUNCIL SCIENT IND RES (IN) 2013-02-13 EP disclosed
EP-2271648-A1 ISOXAZOLINE LINKED PYRROLO [2,1-C][1,4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND THE PROCESS FOR PREPARATTION THEREOF Council of Scientific & Industrial Research (IN) 2011-01-12 EP disclosed
WO-2009118748-A1 ISOXAZOLINE LINKED PYRROLO[2,1-C[1,4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND THE PROCESS FOR PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2009-10-01 WO disclosed