Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900893 | 0.92 | ADORA3 (0.43) | ADORA3ALOX15POLBNPSR1KDM4E | |
| SCHEMBL3714621 | 0.73 | KDM4E (0.44) | ADORA3ALOX15POLBKDM4EALDH1A1 | |
| SCHEMBL18148022 | 0.72 | MAPT (0.45) | ADORA3POLBKDM4EALDH1A1MAPT | |
| SCHEMBL19533508 | 0.72 | KDM4E (0.44) | KDM4EALDH1A1MAPTL3MBTL1GAA | |
| SCHEMBL3464453 | 0.72 | — | — | |
| SCHEMBL25271465 | 0.72 | MGLL (0.36) | ALDH1A1L3MBTL1GAAHSP90AA1 | |
| SCHEMBL16376209 | 0.72 | ADORA3 (0.36) | ADORA3ALOX15POLBNPSR1KDM4E | |
| SCHEMBL18161339 | 0.70 | MAPT (0.49) | ADORA3KDM4EALDH1A1MAPTCHEK1 | |
| SCHEMBL277389 | 0.70 | ALOX15 (0.40) | ADORA3ALOX15POLBKDM4EALDH1A1 | |
| SCHEMBL13112245 | 0.70 | ALOX15 (0.40) | ADORA3ALOX15POLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 244 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3802549-B1 | NOVEL OXOQUINOLIZINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | HOFFMANN LA ROCHE (CH) | 2023-03-01 | — | — | EP | claimed |
| EP-4100381-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-12-14 | — | — | EP | claimed |
| WO-2021158481-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-08-12 | — | — | WO | claimed |
| US-10155021-B2 | Antimicrobial 4-oxoquinolizines | EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC. (US) | 2018-12-18 | — | — | US | claimed |
| EP-2670410-B1 | ANTIMICROBIAL 4-OXOQUINOLIZINES | EMERGENT PRODUCT DEV GAITHERSBURG INC (US) | 2017-12-20 | — | — | EP | claimed |
| US-20170232060-A9 | ANTIMICROBIAL 4-OXOQUINOLIZINES | EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC. | 2017-08-17 | — | — | US | claimed |
| US-20170106045-A1 | ANTIMICROBIAL 4-OXOQUINOLIZINES | EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC. | 2017-04-20 | — | — | US | claimed |
| US-9403818-B2 | Antimicrobial 4-oxoquinolizines | EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC. (US) | 2016-08-02 | — | — | US | claimed |
| EP-2670410-A1 | ANTIMICROBIAL 4-OXOQUINOLIZINES | Evolva SA (CH) | 2013-12-11 | — | — | EP | claimed |
| US-20130252882-A1 | ANTIMICROBIAL 4-OXOQUINOLIZINES | EVOLVA SA (CH) | 2013-09-26 | — | — | US | claimed |
| EP-1064284-B1 | HYPNOTIC BETA-CARBOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS | MACEF (FR) | 2002-03-27 | — | — | EP | claimed |
| EP-1064284-A1 | HYPNOTIC BETA-CARBOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS | MACEF (FR) | 2001-01-03 | — | — | EP | claimed |
| WO-1999047521-A1 | HYPNOTIC β-CARBOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS | MACEF (FR) | 1999-09-23 | — | — | WO | claimed |
| EP-0309260-B1 | 4H-QUINOLIZIN-4-ONE COMPOUNDS EXHIBITING THERAPEUTIC ACTIVITIES | Kissei Pharmaceutical Co., Ltd. (JP) | 1992-01-15 | — | — | EP | claimed |
| US-4935425-A | TREATMENT OF ALLERGIC ASTHMA, RHINITIS, DERMATITIS AND HYPERSENSITIVENESS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1990-06-19 | — | — | US | claimed |
| US-4904657-A | 4H-quinolizin-4-one compounds exhibiting therapeutic activities | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1990-02-27 | — | — | US | claimed |
| US-4877795-A | 4H-quinolizin-4-one compounds useful for the treatment of allergic bronchial asthma, allergic rhinitis atropic dermatitis and the like | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-10-31 | — | — | US | claimed |
| EP-0317295-A2 | 4H-quinolizin-4-one compounds and pharmaceutical compositions containing them | Kissei Pharmaceutical Co., Ltd. (JP) | 1989-05-24 | — | — | EP | claimed |
| EP-0309260-A1 | 4H-Quinolizin-4-one compounds exhibiting therapeutic activities | Kissei Pharmaceutical Co., Ltd. (JP) | 1989-03-29 | — | — | EP | claimed |
| EP-0277755-A1 | 4H-quinolizin-4-one compounds exhibiting therapeutic activities | Kissei Pharmaceutical Co. Ltd. (JP) | 1988-08-10 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10155021-B2 | Antimicrobial 4-oxoquinolizines | DCAF15, CUL4A, CUL4B | ADORA3 4484/4885ALOX15 1283/4885POLB 496/4885 |
| US-20170106045-A1 | ANTIMICROBIAL 4-OXOQUINOLIZINES | CUL4A, DCAF15, CUL4B | ADORA3 4499/4885ALOX15 1270/4885POLB 446/4885 |
| US-20170232060-A9 | ANTIMICROBIAL 4-OXOQUINOLIZINES | CUL4A, DCAF15, CUL4B | ADORA3 4499/4885ALOX15 1270/4885POLB 446/4885 |
| US-20130252882-A1 | ANTIMICROBIAL 4-OXOQUINOLIZINES | CUL4A, DCAF15, CUL4B | ADORA3 4499/4885ALOX15 1270/4885POLB 446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.