Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 7/20 | 0.46 |
| ▸ | PDE4A | P27815 | 6/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10143788 | 0.78 | PDE4A (0.51) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL10143824 | 0.78 | PDE4A (0.51) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL14216102 | 0.73 | HTR4 (0.44) | PDE4DPDE4APDE4BPDE4CHRH1 | |
| SCHEMBL10143872 | 0.72 | PDE4A (0.39) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL10143828 | 0.72 | HTR4 (0.49) | — | |
| SCHEMBL13261137 | 0.71 | MCHR1 (0.47) | HRH1CCR3KCNH2 | |
| SCHEMBL10144544 | 0.71 | MCHR1 (0.47) | HRH1CCR3KCNH2 | |
| SCHEMBL5148402 | 0.70 | MEN1 (0.60) | KMT2AMEN1NPC1USP2RAB9A | |
| SCHEMBL28034904 | 0.70 | NPC1 (0.59) | KMT2AMEN1NPC1RAB9AHDAC1 | |
| SCHEMBL5606505 | 0.69 | MEN1 (0.64) | KMT2AMEN1NPC1USP2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079743-B1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD (GB) | 2012-01-25 | — | — | EP | disclosed |