Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.51 |
| ▸ | MARS1 | P56192 | 2/20 | 0.47 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | SLC5A7 | Q9GZV3 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | IARS1 | P41252 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10143788 | 1.00 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DMARS1 | |
| SCHEMBL10143828 | 0.83 | HTR4 (0.49) | HTR4 | |
| SCHEMBL13261137 | 0.82 | MCHR1 (0.47) | HTR4HRH1CCR3KCNH2 | |
| SCHEMBL10144544 | 0.82 | MCHR1 (0.47) | HTR4HRH1CCR3KCNH2 | |
| SCHEMBL10144478 | 0.82 | CACNA1B (0.49) | PDE4APDE4BPDE4CPDE4DHTR4 | |
| SCHEMBL14216102 | 0.82 | HTR4 (0.44) | PDE4APDE4BPDE4CPDE4DHTR4 | |
| SCHEMBL10143826 | 0.78 | PDE4D (0.46) | PDE4APDE4BPDE4CPDE4DHRH1 | |
| SCHEMBL12427355 | 0.78 | CXCR4 (0.67) | PDE4APDE4BPDE4CPDE4DHTR4 | |
| SCHEMBL28787252 | 0.78 | LMNA (0.64) | MARS1HTR4RAB9AIARS1MEN1 | |
| SCHEMBL13175548 | 0.77 | LMNA (0.52) | MARS1HTR4HRH1CCR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079743-B1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD (GB) | 2012-01-25 | — | — | EP | disclosed |
| WO-2008050096-A1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-02 | — | — | WO | disclosed |