SCHEMBL1014385

SCHEMBL1014385

NCN1C(=O)c2ccccc2C1=O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.54
CA9 Q16790 2/20 0.54
GLS O94925 1/20 0.54
ALDH1A1 P00352 2/20 0.50
CASP3 P42574 3/20 0.48
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
DRD3 P35462 1/20 0.47
PKM P14618 1/20 0.47
HEXA P06865 1/20 0.47
HEXB P07686 1/20 0.47
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
SENP8 Q96LD8 1/20 0.47
SENP7 Q9BQF6 1/20 0.47
SENP6 Q9GZR1 1/20 0.47
GAA P10253 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9429609 0.98 CA12 (0.52) CA12CA9GLSALDH1A1CASP3
SCHEMBL1309018 0.81 HEXA (0.69) GLSCASP3MEN1KMT2AHEXA
SCHEMBL29560926 0.81 HEXA (0.69) GLSCASP3MEN1KMT2AHEXA
SCHEMBL13207607 0.81 HEXA (0.73) ALDH1A1MEN1KMT2AHEXAHEXB
SCHEMBL19245282 0.80 TERT (0.50) CA12CA9ALDH1A1CA1CA2
Hydrochloric Acid SCHEMBL1975097 0.79 HEXA (0.67) CA9GLSCASP3CA1CA2
Hydrochloric Acid SCHEMBL29556155 0.79 HEXA (0.67) CA9GLSCASP3CA1CA2
SCHEMBL2604740 0.79 CA12 (0.58) CA12CA9GLSALDH1A1CASP3
SCHEMBL6699936 0.79 GLS (0.71) CA12CA9GLSCASP3NPC1
SCHEMBL4063836 0.78 HEXA (0.71) GLSMEN1KMT2AHEXAHEXB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1242007-A Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising such compounds, and methods of inhibiting beta amyloid peptide release and/or its synthesis using such compounds ELAND PHARMACEUTICAL CORP (US) 2000-01-19 CN claimed
JP-10245502-A None JP disclosed
JP-10245501-A None JP disclosed
WO-2024112641-A1 FERMENTED PLANT AND MICROBIAL-BASED FOOD PRODUCTS THE CHEESE DESIGN LLC (US) 2024-05-30 WO disclosed
WO-2024041737-A1 A COMPUTER-IMPLEMENTED METHOD FOR GENERATING & USING A HYDROGEN FUEL STATION ACCESS POLICY VOLVO TRUCK CORPORATION (SE) 2024-02-29 WO disclosed
US-11207416-B2 Compositions and methods for targeted RNA delivery VERVE THERAPEUTICS, INC. (US) 2021-12-28 US disclosed
US-20210299261-A1 COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY VERVE THERAPEUTICS, INC. 2021-09-30 US disclosed
WO-2020136163-A1 LUBRICANT COMPOSITION FOR BALL JOINTS SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 2020-07-02 WO disclosed
EP-2563123-B1 NOVEL BETA 3 ADRENERGIC RECEPTOR AGONISTS MERCK SHARP & DOHME (US) 2018-04-25 EP disclosed
US-9828352-B2 Phenyl carbamates and their use as inhibitors of the fatty acid amide hydrolase (FAAH) enzyme and modulators of the D3 dopamine receptor (D3DR) FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) 2017-11-28 US disclosed
WO-2017194613-A2 METHOD, ARRAY AND USE THEREOF IMMUNOVIA AB (SE) 2017-11-16 WO disclosed
CN-106432047-A Synthesis method of astemizole drug intermediate N-(4-fluorobenzyl)phthalimide 厦门市凯尔利信息科技有限公司 2017-02-22 CN disclosed
US-9550744-B2 Vitamin C prodrugs and uses thereof UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2017-01-24 US disclosed
CN-105523989-A Synthetic method of astemizole drug intermediate N-(4-fluorobenzyl)phthalimide CHENGDU QIESITE TECH CO LTD 2016-04-27 CN disclosed
EP-2042308-B1 Planographic printing plate precursor FUJIFILM CORP (JP) 2011-02-23 EP disclosed
EP-2042305-B1 Planographic printing plate precursor FUJIFILM CORP (JP) 2011-01-12 EP disclosed
EP-2042305-A2 Planographic printing plate precursor FUJIFILM Corporation (JP) 2009-04-01 EP disclosed
JP-H10245502-A PIGMENT COMPOSITION AND REPARATION THEREOF TOYO INK MFG CO LTD 1998-09-14 JP disclosed
JP-H10245501-A PIGMENT COMPOSITION AND PREPARATION THEREOF TOYO INK MFG CO LTD 1998-09-14 JP disclosed
US-4950770-A Psoralens aminomethylation ELDER PHARMACEUTICALS, INC. (US) 1990-08-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11207416-B2 Compositions and methods for targeted RNA delivery PCSK9, LDLR, PCSK7 CA12 3864/4885CA9 3778/4885GLS 4141/4885
US-20210299261-A1 COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY PCSK9, LDLR, PCSK7 CA12 3864/4885CA9 3778/4885GLS 4141/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.