Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13845690 | 0.83 | RPS6KA3 (0.50) | SMN1; SMN2NPC1RAB9ARPS6KA3ALDH1A1 | |
| SCHEMBL13845779 | 0.80 | RPS6KA3 (0.48) | SMN1; SMN2NPC1RAB9AGAAADORA2A | |
| SCHEMBL14072191 | 0.80 | RPS6KA3 (0.47) | SMN1; SMN2NPC1RAB9AADORA2AADORA1 | |
| SCHEMBL13845752 | 0.80 | RPS6KA3 (0.46) | SMN1; SMN2NPC1RAB9AGAAHTT | |
| SCHEMBL14543365 | 0.79 | RPS6KA3 (0.51) | SMN1; SMN2NPC1RAB9AADORA2AADORA3 | |
| SCHEMBL14072168 | 0.79 | RPS6KA3 (0.48) | NPC1RAB9ARPS6KA3ALDH1A1HPGD | |
| SCHEMBL23745118 | 0.79 | RPS6KA3 (0.43) | SMN1; SMN2NPC1RAB9AGAAADORA2A | |
| SCHEMBL14072200 | 0.77 | RPS6KA3 (0.47) | SMN1; SMN2NPC1RAB9AADORA2AADORA1 | |
| SCHEMBL2390274 | 0.77 | RPS6KA3 (0.45) | NPC1RAB9AADORA2AADORA1ADORA3 | |
| SCHEMBL2389890 | 0.77 | RPS6KA3 (0.45) | NPC1RAB9AADORA2AADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382193-B2 | Processes for forming amide bonds and compositions related thereto | EMORY UNIVERSITY (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382193-B2 | Processes for forming amide bonds and compositions related thereto | EMORY UNIVERSITY (US) | 2016-07-05 | — | — | US | disclosed |
| US-20150315129-A1 | PROCESSES FOR FORMING AMIDE BONDS AND COMPOSITIONS RELATED THERETO | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-05 | — | — | US | disclosed |
| US-20150315129-A1 | PROCESSES FOR FORMING AMIDE BONDS AND COMPOSITIONS RELATED THERETO | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-05 | — | — | US | disclosed |
| US-8921599-B2 | Processes for forming amide bonds and compositions related thereto | EMORY UNIVERSITY (US) | 2014-12-30 | — | — | US | disclosed |
| US-8921599-B2 | Processes for forming amide bonds and compositions related thereto | EMORY UNIVERSITY (US) | 2014-12-30 | — | — | US | disclosed |
| US-20120107902-A1 | Processes For Forming Amide Bonds And Compositions Related Thereto | EMORY UNIVERSITY (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150315129-A1 | PROCESSES FOR FORMING AMIDE BONDS AND COMPOSITIONS RELATED THERETO | TMT1A, LPO, GSTO1 | SMN1; SMN2 3807/4885NPC1 4318/4885RAB9A 1801/4885 |
| US-20120107902-A1 | Processes For Forming Amide Bonds And Compositions Related Thereto | TMT1A, LPO, GSTO1 | SMN1; SMN2 3807/4885NPC1 4318/4885RAB9A 1801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.