Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.59 |
| ▸ | NCF1 | P14598 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27789191 | 0.88 | CA2 (0.68) | NOS1NCF1ALDH1A1CA2HIF1A | |
| SCHEMBL29865404 | 0.87 | HIF1A (0.73) | NOS1NCF1ALDH1A1CA2HIF1A | |
| SCHEMBL3829994 | 0.87 | HIF1A (0.73) | NOS1NCF1ALDH1A1CA2HIF1A | |
| SCHEMBL27828922 | 0.86 | NCF1 (0.55) | NOS1NCF1ALDH1A1CA2HIF1A | |
| SCHEMBL4164832 | 0.85 | NCF1 (0.57) | NOS1NCF1ALDH1A1CA2HIF1A | |
| Hydrochloric Acid SCHEMBL9837720 | 0.85 | HIF1A (0.71) | NOS1NCF1ALDH1A1CA2HIF1A | |
| SCHEMBL20658808 | 0.85 | HIF1A (0.71) | NOS1NCF1ALDH1A1CA2HIF1A | |
| SCHEMBL20496772 | 0.85 | NCF1 (0.57) | NOS1NCF1ALDH1A1CA2HIF1A | |
| SCHEMBL4164833 | 0.85 | NCF1 (0.61) | NOS1NCF1ALDH1A1CA2HIF1A | |
| SCHEMBL29864585 | 0.85 | NCF1 (0.61) | NOS1NCF1ALDH1A1CA2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034466-A1 | NOVEL FIVE-MEMBERED RING COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-02-10 | — | — | US | disclosed |
| US-20110034466-A1 | NOVEL FIVE-MEMBERED RING COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-02-10 | — | — | US | disclosed |
| US-20110034466-A1 | NOVEL FIVE-MEMBERED RING COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-02-10 | — | — | US | disclosed |
| EP-2272835-A1 | NOVEL FIVE-MEMBERED RING COMPOUND | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131171-A1 | NOVEL FIVE-MEMBERED RING COMPOUND | 大日本住友製薬株式会社 (JP) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034466-A1 | NOVEL FIVE-MEMBERED RING COMPOUND | CCL11, CCR1, CCR10 | NOS1 355/4885NCF1 102/4885ALDH1A1 2564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.